生物
转录组
表型
电池类型
神经科学
基因
计算生物学
遗传学
细胞
基因表达
作者
Wanjing Huang,Qiang Xu,Jing Su,Lei Tang,Zhao-Zhe Hao,Chuan Xu,Ruifeng Liu,Yuhui Shen,Xuan Sang,Nana Xu,Xiaoxiu Tie,Zhichao Miao,Xialin Liu,Ying Xu,Feng Liu,Yizhi Liu,Sheng Liu
出处
期刊:Cell Reports
[Elsevier]
日期:2022-09-01
卷期号:40 (11): 111322-111322
被引量:21
标识
DOI:10.1016/j.celrep.2022.111322
摘要
Retinal ganglion cells (RGCs) are the brain’s gateway to the visual world. They can be classified into different types on the basis of their electrophysiological, transcriptomic, or morphological characteristics. Here, we characterize the transcriptomic, morphological, and functional features of 472 high-quality RGCs using Patch sequencing (Patch-seq), providing functional and morphological annotation of many transcriptomic-defined cell types of a previously established RGC atlas. We show a convergence of different modalities in defining the RGC identity and reveal the degree of correspondence for well-characterized cell types across multimodal data. Moreover, we complement some RGC types with detailed morphological and functional properties. We also identify differentially expressed genes among ON, OFF, and ON-OFF RGCs such as Vat1l, Slitrk6, and Lmo7, providing candidate marker genes for functional studies. Our research suggests that the molecularly distinct clusters may also differ in their roles of encoding visual information.
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