上睑下垂
胞吐
溶酶体
炎症体
细胞生物学
半胱氨酸蛋白酶1
半胱氨酸蛋白酶
促炎细胞因子
化学
细胞外
分泌物
程序性细胞死亡
生物
炎症
细胞凋亡
生物化学
免疫学
受体
酶
作者
Wendy P. Loomis,Tessa Bergsbaken
出处
期刊:Methods in molecular biology
日期:2023-01-01
卷期号:: 171-178
被引量:1
标识
DOI:10.1007/978-1-0716-3040-2_14
摘要
Inflammasome-mediated activation of inflammatory caspases (caspase-1, caspase-4, caspase-5, caspase-11) initiates a cascade of cellular events that lead to proinflammatory cell death, or pyroptosis. Proteolytic cleavage of gasdermin D results in the formation of transmembrane pores that allow the release of mature cytokines IL-1β and IL-18. Gasdermin pores also allow calcium influx through the plasma membrane, triggering the fusion of lysosomal compartments with the cell surface and release of their contents into the extracellular milieu in a process termed lysosome exocytosis. This chapter outlines methods for measuring calcium flux, lysosome exocytosis, and membrane disruption after inflammatory caspase activation.
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