喹诺酮类
药效团
药品
抗生素
抗药性
抗菌剂
计算生物学
药理学
生物
微生物学
生物信息学
作者
Jun Wang,Shi Yumin,Yan Heng
标识
DOI:10.4155/fmc-2023-0002
摘要
Quinolone derivatives, represented by fluoroquinolones, have emerged as the most commonly prescribed antibacterials for the treatment of various bacterial infections. In particular, the combination of a quinolone moiety with other antibacterial pharmacophores has the potential to act on different drug targets, which in turn, overcome drug resistance. Accordingly, quinolone hybrids are useful prototypes for fighting drug-resistant pathogens. The purpose of the present review is to provide an emphasis on the current scenario of quinolone hybrids with potential antibacterial activity against drug-resistant pathogens, covering articles published in the past 10 years. The structure–activity relationships, various aspects of rational design and mechanisms of action are also discussed to facilitate further rational development of more effective candidates.
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