SGLT2-inhibitors are effective and safe in the elderly: The SOLD study

医学 恩帕吉菲 达帕格列嗪 卡格列净 内科学 糖尿病 肾功能 糖化血红素 不利影响 人口 危险系数 二甲双胍 2型糖尿病 体质指数 胰岛素 置信区间 内分泌学 环境卫生
作者
Maria Elena Lunati,Vincenzo Cimino,Alessandra Gandolfi,Matteo Trevisan,Laura Montefusco,Ida Pastore,Camilla Pace,Nazarena Betella,Giuseppe Favacchio,Monica Bulgheroni,Loredana Bucciarelli,Giulia Massari,Cristina Mascardi,Angela Girelli,Paola Silvia Morpurgo,Franco Folli,Livio Luzi,Marco Mirani,Basilio Pintaudi,Federico Bertuzzi,Cesare Berra,Paolo Fiorina
出处
期刊:Pharmacological Research [Elsevier]
卷期号:183: 106396-106396 被引量:27
标识
DOI:10.1016/j.phrs.2022.106396
摘要

Sodium-glucose co-transporter-2 inhibitors (SGLT2i) may have important benefits for the elderly with type 2 diabetes (T2D), however some safety concerns still limit their use in patients over 70 years of age. The SOLD study (SGLT2i in Older Diabetic patients) is a multicenter study, aimed to evaluate the effectiveness and safety of SGLT2i in the older diabetic patients in a real-life setting. We analyzed a population of 739 adults (mean age 75.4 ± 3.9 years, M/F 420/319) with T2D, which started a SGLT2i-based treatment after the age of 70, with at least one year of follow-up. Data were collected at baseline, at 6 and 12 months of follow-up. SGLT2i (37.5% Empagliflozin, 35.7% Dapagliflozin, 26.1% Canagliflozin, 0.7% Ertugliflozin) were an add-on therapy to Metformin in 88.6%, to basal insulin in 36.1% and to other antidiabetic drugs in 29.6% of cases. 565 subjects completed the follow up, while 174 (23.5%) discontinued treatment due to adverse events which were SGLT2i related. A statistically significant reduction of glycated hemoglobin (baseline vs 12 months: 7.8 ± 1.1 vs 7.1 ± 0.8%, p < 0.001) and body mass index values (baseline vs 12 months: 29.2 ± 4.7 vs 28.1 ± 4.5 kg/m2, p < 0.001) were evident during follow-up. Overall, estimated glomerular filtration rate remained stable over time, with significant reduction of urinary albumin excretion. In the subgroup of patients which were ≥ 80 years, a significant improvement in glycated hemoglobin values without renal function alterations was evident. Overall discontinuation rate during the follow-up period was different across age groups, being urinary tract infections and worsening of renal function the most common cause. SGLT2i are well-tolerated and safe in the elderly and appear as an effective therapeutic option, though some caution is also suggested, especially in more fragile subjects.
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