化学
结合
组合化学
模块化设计
分子间力
简单(哲学)
抗体-药物偶联物
块(置换群论)
分子
抗体
有机化学
单克隆抗体
程序设计语言
计算机科学
哲学
几何学
数学
认识论
数学分析
免疫学
生物
作者
Fabien Serpier,Laurent Petit,Logan Salamone,Martin Lepeintre,Vincent Revil-Baudard
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2023-04-04
卷期号:55 (14): 2177-2185
标识
DOI:10.1055/s-0042-1751436
摘要
Abstract An efficient synthesis of 4-mercapto-4-methylpentanoic acid, a fragment notably found in Antibody-Drug Conjugates (ADCs), is reported using an intermolecular radical transfer reaction as the pivotal step. The reported approach displays several advantages over more traditional routes and is compatible with the chemistry involved in the construction of ADCs. Original analogues of the molecule of interest can be readily accessed using the method developed.
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