化学
线粒体
配体(生物化学)
硫氧还蛋白还原酶
生物物理学
材料科学
硫氧还蛋白
生物化学
酶
生物
受体
作者
Yongli Hua,Zi‐Hui Shao,Aoqiang Zhai,Lijun Zhang,Zhao‐Yang Wang,Ge Zhao,Fuwei Xie,Junqi Liu,Xueli Zhao,Xiaoyuan Chen,Shuang‐Quan Zang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-04-06
卷期号:17 (8): 7837-7846
被引量:14
标识
DOI:10.1021/acsnano.3c01068
摘要
Atomically precise gold clusters play an important role in the development of high-Z-element-based radiosensitizers, due to their intriguing structural diversity and advantages in correlating structures and properties. However, the synthesis of gold clusters with both water-solubility and single-crystal structure remains a challenge. In this study, atomically precise Au25(S-TPP)18 clusters (TPP-SNa = sodium 3-(triphenylphosphonio)propane-1-thiolate bromide) showing both mitochondria-targeting ability and water-solubility were obtained via ligand design for enhanced radioimmunotherapy. Compared with Au25(SG)18 clusters (SG = glutathione), Au25(S-TPP)18 exhibited higher radiosensitization efficiency due to its mitochondria-targeting ability, higher ROS production capacity, and obvious inhibition upon thioredoxin reductase (TrxR). In addition, the enhanced radiotherapy-triggered abscopal effect in combination with checkpoint blockade displayed effective growth inhibition of distant tumors. This work reveals the ligand-regulated organelle targeting ability of metal clusters by which feasible strategies to promote their application in precise theranostics could be realized.
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