天然产物
计算生物学
自然(考古学)
产品(数学)
计算机科学
生物
生物化学
数学
古生物学
几何学
作者
Carolina Cano-Prieto,Agustina Undabarrena,Ana Calheiros de Carvalho,Jay D. Keasling,Pablo Cruz-Morales
出处
期刊:PubMed
日期:2024-04-19
标识
DOI:10.1146/annurev-biochem-032620-104731
摘要
Natural products have played significant roles as medicine and food throughout human history. Here, we first provide a brief historical overview of natural products, their classification, biosynthetic origins, and the microbiological and genetic methods used for their discovery. We also describe and discuss the technologies that revolutionized the field, which transitioned from classic genetics to genome-centric discovery approximately two decades ago. We then highlight the most recent advancements and approaches in the current postgenomic era, in which genome mining is a standard operation and high-throughput analytical methods allow parallel discovery of genes and molecules at an unprecedented pace. Finally, we discuss the new challenges faced by the field of natural products and the future of systematic heterologous expression and strain-independent discovery, which promises to deliver more molecules in vials than ever before.
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