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The chemical composition, protective effect of Rheum officinale leaf juice and its mechanism against dextran sulfate sodium-induced ulcerative colitis

溃疡性结肠炎 化学 多糖 芦丁 结肠炎 半乳糖 功能性食品 果胶 氧化应激 消炎药 食品科学 药理学 生物化学 抗氧化剂 生物 医学 病理 疾病 免疫学
作者
Lixia Dai,Xinyuan Cao,Xiaolou Miao,Xiaorong Yang,Jiyu Zhang,Xiaofei Shang
出处
期刊:Phytomedicine [Elsevier]
卷期号:129: 155653-155653 被引量:1
标识
DOI:10.1016/j.phymed.2024.155653
摘要

Rhubarb is widely distributed and cultivated worldwide, and its leaves presented antioxidant activity and could be used as food additive. However, the chemical ingredients, and protective effect of Rheum officinale leaf juice (JROL) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) are still unclear. This paper sought to the characterisation and functional properties of JROL, and explore the underlying mechanism on UC mice. UPLC-ESI-Q-TOF/MS and other analytical instruments were employed to determine the chemical ingredients of JROL. After inducing UC model using 3% DSS, multiple biological methods were used to evaluate its protective effect and the potential mechanism. JROL is rich in proximate compositions and minerals and has high nutritional value, and contains reducing sugars, polysaccharides and pectin. Fifteen compounds were identified using UPLC-ESI-Q-TOF/MS. Among them, rutin has the highest content (2.22%) in UPLC analysis. JROL presented protective effect on DSS-induced UC, and alleviated morphological alterations and ultra-structural feature of tissue, and the polysaccharides and flavonoids may contribute to its protective effect. JROL inhibited NF-κB/NLRP3 signaling pathway to alleviate inflammatory response, oxidative stress and intestinal injury by decreasing the expression of p-p65, p-IκBα, NLRP3, ASC, etc.. Moreover, it up-regulated the expression of tight junction proteins, and re-balanced the disturbance of gut microbiota to regulate the inflammatory response. Finally, a correlation among the inflammatory response, NF-κB/NLRP3 pathway and gut microbiota was established. Moreover, JROL presented the safety in the acute toxicity test. JROL could be used as a potential new source for treating UC.
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