Left Ventricular Trabeculations at Cardiac MRI: Reference Ranges and Association with Cardiovascular Risk Factors in UK Biobank

Applying automated segmentation to UK Biobank MRI scans, hypertension, higher body mass index, and higher physical activity levels were associated with increased left ventricle trabeculations in healthy middle-aged White adults.Key Results:1.In a cross-sectional secondary analysis of prospectively collected data from the UK Biobank, applying automated segmentation to cardiac MRI scans, the trabeculated left ventricular (LV) mass was significantly higher in middle-aged White adults with established cardiovascular risk factors (n = 28 672) compared with a healthy reference group (n = 7384) for both men (median (IQR) of 6.8 g (5.1, 9.0) vs. 6.3 g (4.7, 8.5), P<.001) and women (5.1g (3.8, 6.7) vs. 4.6 g ( 3.4, 6.0) P<.001).2. Hypertension (β=0.42,95% CI: 0.36, 0.48, P<.001), higher body mass index (β=0.66,95% CI: 0.63, 0.68, P<.001), and higher physical activity levels (β=0.15,95% CI: 0.12, 0.17, P<.001), were associated with increased LV trabeculation.3. Age-and sex-specific reference ranges of trabeculated LV mass values in a middle-aged healthy White population were established.