Endocan: A biomarker for endothelial dysfunction and inflammation, linking maternal obesity and pediatric obesity in a cohort of preterm neonates

医学 肥胖 后代 生物标志物 前瞻性队列研究 妊娠期 怀孕 队列 出生体重 队列研究 内皮功能障碍 产科 全身炎症 内科学 儿科 生理学 炎症 生物化学 生物 化学 遗传学
作者
Emily Holthaus,Marie S. O’Neill,Walter Jeske,Phillip J. DeChristopher,Jean R. Goodman,Loretto Glynn,S. Levin,Jonathan Muraskas
出处
期刊:European Journal of Obstetrics & Gynecology and Reproductive Biology [Elsevier BV]
卷期号:297: 132-137
标识
DOI:10.1016/j.ejogrb.2024.04.013
摘要

Objectives Numerous animal and epidemiologic studies have demonstrated a positive association between maternal obesity in pregnancy and obesity in offspring. The biologic mechanisms of this association remain under investigation. One proposed mechanism includes fetoplacental endothelial dysfunction secondary to inflammation. Endocan is a relatively new biomarker for endothelial dysfunction and inflammation. Our objectives were to examine (1) the association between maternal obesity and neonatal serum endocan at birth, and (2) the association between neonatal serum endocan at birth and pediatric obesity at 24–36 months of age. Study Design This was a secondary analysis of a prospective cohort of neonates born < 33 weeks gestation. Serum endocan was collected within 48 hours of birth. Serum endocan levels were compared in neonates born to obese mothers vs. those born to non-obese mothers. BMI data were retrospectively collected from cohort neonates between 24 and 36 months of age. Results The analysis included 120 mother/neonate dyads. Neonates born to obese mothers had higher median serum endocan at birth compared to neonates born to non-obese mothers (299 ng/L [205–586] vs. 251 ng/L [164–339], p = 0.045). In a linear regression modeled on neonatal serum endocan level, maternal obesity had a statistically significant positive association (p = 0.021). Higher mean serum endocan level at birth was associated with pediatric obesity between 24 and 36 months (obese vs. non-obese offspring; 574 ng/L (222) vs. 321 ng/L (166), p = 0.005). Conclusions In our cohort of preterm neonates, elevated serum endocan at birth was associated with both maternal obesity and downstream pediatric obesity. More research is needed to understand intergenerational transmission of obesity. A large focus has been on epigenetic modification. Endothelial dysfunction and inflammation may play important roles in these pathways. Effective biomarkers, including endocan, may also serve as intermediate outcomes in future pregnancy research.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
dd发布了新的文献求助80
刚刚
mouxq发布了新的文献求助10
1秒前
归尘应助大吉岭采纳,获得10
2秒前
海东来给凩飒的求助进行了留言
2秒前
蜡笔完成签到,获得积分10
2秒前
九姑娘完成签到 ,获得积分10
3秒前
vvvaee发布了新的文献求助10
3秒前
量子星尘发布了新的文献求助10
5秒前
lsy完成签到,获得积分10
6秒前
Sensons完成签到,获得积分10
6秒前
嘟嘟发布了新的文献求助10
7秒前
8秒前
金旭完成签到,获得积分10
9秒前
RG完成签到,获得积分10
9秒前
9秒前
10秒前
FLZLC发布了新的文献求助10
11秒前
长白完成签到,获得积分10
11秒前
11秒前
11秒前
诸天蓉发布了新的文献求助10
11秒前
敏哇哇哇发布了新的文献求助10
12秒前
13秒前
许雨青发布了新的文献求助30
13秒前
09chenyun完成签到,获得积分10
14秒前
暖暖完成签到,获得积分10
15秒前
刘尹发布了新的文献求助30
15秒前
15秒前
tuanheqi应助松鼠15111采纳,获得100
16秒前
pl脆脆发布了新的文献求助10
16秒前
17秒前
汤圆完成签到,获得积分10
19秒前
19秒前
领导范儿应助明亮依琴采纳,获得10
20秒前
21秒前
21秒前
胡浩完成签到,获得积分10
21秒前
敏哇哇哇完成签到,获得积分10
21秒前
雪兔妹妹完成签到 ,获得积分10
21秒前
22秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance 500
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970008
求助须知:如何正确求助?哪些是违规求助? 3514711
关于积分的说明 11175563
捐赠科研通 3250077
什么是DOI,文献DOI怎么找? 1795198
邀请新用户注册赠送积分活动 875630
科研通“疑难数据库(出版商)”最低求助积分说明 804931