表征(材料科学)
抗体
计算机科学
化学
材料科学
纳米技术
医学
免疫学
作者
Liesa Verscheure,Shauni Detremmerie,Hilde Stals,Jelle De Vos,Pat Sandra,Frédéric Lynen,Filip Borgions,Koen Sandra
标识
DOI:10.1016/j.chroma.2024.464947
摘要
Monoclonal antibodies (mAbs) are large and highly heterogeneous species typically characterized using a plethora of analytical methodologies. There is a trend within the biopharmaceutical industry to combine several of these methods in one analytical platform to simultaneously assess multiple structural attributes. Here, a protein analyzer for the fully automated middle-up and bottom-up liquid chromatography-mass spectrometry (LC-MS) analysis of charge, size and hydrophobic variants is described. The multidimensional set-up combines a multi-method option in the first dimension (
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