癌细胞
转移
细胞外
阿皮拉酶
运动性
癌症研究
乳腺癌
细胞迁移
癌症
细胞内
生物
细胞生物学
细胞
医学
内科学
生物化学
作者
Ying Liu,Youfeng Geng,Hui Yang,Han Yang,Yanting Zhou,Hongquan Zhang,Xin‐Xia Tian,Weigang Fang
标识
DOI:10.1016/j.canlet.2018.04.043
摘要
Our previous work has demonstrated that extracellular ATP is an important pro-invasive factor, and in this study, we tapped into a possible mechanism involved. We discovered that ATP could upregulate both the intracellular expression and secretion of S100A4 in breast cancer cells and fibroblasts. Apart from stimulating breast cancer cell motility via intracellular S100A4, ATP enhanced the ability of breast cancer cells to transform fibroblasts into cancer-associated fibroblast (CAF)-like cells, which in turn secreted S100A4 to further promote cancer cell motility. Both apyrase and niclosamide treatments could inhibit metastasis of inoculated tumors to lung, liver and kidney in mice model, and CAFs from these treated tumors exhibited weakened migration-stimulating capacity for breast cancer cells. Collectively, our data indicate that extracellular ATP promotes the interactions between breast cancer cells and fibroblasts, which work collaboratively via production of S100A4 to exacerbate breast cancer metastasis.
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