Specific expression network analysis of diabetic nephropathy kidney tissue revealed key methylated sites

小桶 表观遗传学 基因 生物 遗传学 DNA甲基化 发病机制 基因表达 计算生物学 免疫学 转录组
作者
Yanzhe Wang,Wenwei Xu,Dingyu Zhu,Nan Zhang,Yonglan Wang,Miao Ding,Xinmiao Xie,Linlin Sun,Xiaoxia Wang
出处
期刊:Journal of Cellular Physiology [Wiley]
卷期号:233 (10): 7139-7147 被引量:23
标识
DOI:10.1002/jcp.26638
摘要

Diabetic nephropathy (DN) is one of the most common and serious complication in diabetes patients. However, the evidences of gene regulation mechanism and epigenetic modification with DN remain unclear. Therefore, it is necessary to search regulating genes for early diagnosis on DN. We identified tissue specific genes through mining the gene expression omnibus (GEO) public database, enriched function by gene ontology (GO), and kyoto encyclopedia of genes and genomes (KEGG) analysis, and further compared tissue-specific network. Meanwhile, combining with differentially methylated sites, we explored the association epigenetic modification with the pathogenesis of DN. Glomeruli (Glom) may be the main tissue of signal recognition and tubulointerstitium (Tub) is mainly associated with energy metabolism in the occurrence of DN. By comparing tissue-specific networks between Glom and Tub, we screened 319 genes, which played an important role in multiple tissue on kidney. Among them, ANXA2, UBE2L6, MME, IQGAP, SLC7A7, and PLG played a key role in regulating the incidence of DN. Besides, we also identified 1 up-regulated gene (PIK3C2B) and 39 down-regulated genes (POLR2G, DDB1, and ZNF230, etc.) in the methylated data of Glom specific genes. In the Tub specific expressed genes, we identified two hypo-methylated genes (PPARA and GLS). Tub mainly caused abnormal energy metabolism, and Glom caused the changes in cell connections and histone modification. By analyzing differentially methylated sites and tissue-specific expressed genes, we found the change of methylated status about the core regulating genes may be a potential factor in the pathogenesis of DN.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
听白完成签到 ,获得积分10
刚刚
威武白桃完成签到,获得积分10
刚刚
2秒前
七星嘿咻完成签到,获得积分10
2秒前
中央戏精学院完成签到,获得积分10
3秒前
Strongly完成签到,获得积分10
4秒前
luan发布了新的文献求助10
5秒前
CipherSage应助Fan采纳,获得10
6秒前
lisastream完成签到,获得积分10
7秒前
郑嘻嘻完成签到,获得积分10
9秒前
爆米花应助称心的蛟凤采纳,获得10
10秒前
充电宝应助lisastream采纳,获得10
11秒前
超甜大西瓜完成签到,获得积分10
12秒前
jgyyugyfy完成签到,获得积分10
14秒前
CipherSage应助子车曼香采纳,获得10
16秒前
漂亮火腿肠完成签到 ,获得积分10
18秒前
19秒前
比奇堡不下雪完成签到,获得积分10
20秒前
Phosphene完成签到,获得积分0
20秒前
22秒前
23秒前
24秒前
有思想完成签到,获得积分10
26秒前
King16发布了新的文献求助10
29秒前
hh发布了新的文献求助10
29秒前
暮霭沉沉应助研友_ZA2yd8采纳,获得10
30秒前
31秒前
adam完成签到,获得积分10
32秒前
喜悦的绮露完成签到,获得积分10
32秒前
我刚上小学完成签到,获得积分10
33秒前
33秒前
科研通AI2S应助科研通管家采纳,获得10
34秒前
34秒前
34秒前
慕青应助科研通管家采纳,获得10
34秒前
巴拉拉完成签到,获得积分10
34秒前
35秒前
35秒前
子车曼香完成签到,获得积分10
35秒前
hh完成签到,获得积分10
37秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3193765
求助须知:如何正确求助?哪些是违规求助? 2842801
关于积分的说明 8040855
捐赠科研通 2506900
什么是DOI,文献DOI怎么找? 1339459
科研通“疑难数据库(出版商)”最低求助积分说明 638755
邀请新用户注册赠送积分活动 607557