Specific expression network analysis of diabetic nephropathy kidney tissue revealed key methylated sites

小桶 表观遗传学 基因 生物 遗传学 DNA甲基化 发病机制 基因表达 计算生物学 免疫学 转录组
作者
Yanzhe Wang,Wenwei Xu,Dingyu Zhu,Nan Zhang,Yonglan Wang,Miao Ding,Xinmiao Xie,Linlin Sun,Xiaoxia Wang
出处
期刊:Journal of Cellular Physiology [Wiley]
卷期号:233 (10): 7139-7147 被引量:23
标识
DOI:10.1002/jcp.26638
摘要

Diabetic nephropathy (DN) is one of the most common and serious complication in diabetes patients. However, the evidences of gene regulation mechanism and epigenetic modification with DN remain unclear. Therefore, it is necessary to search regulating genes for early diagnosis on DN. We identified tissue specific genes through mining the gene expression omnibus (GEO) public database, enriched function by gene ontology (GO), and kyoto encyclopedia of genes and genomes (KEGG) analysis, and further compared tissue-specific network. Meanwhile, combining with differentially methylated sites, we explored the association epigenetic modification with the pathogenesis of DN. Glomeruli (Glom) may be the main tissue of signal recognition and tubulointerstitium (Tub) is mainly associated with energy metabolism in the occurrence of DN. By comparing tissue-specific networks between Glom and Tub, we screened 319 genes, which played an important role in multiple tissue on kidney. Among them, ANXA2, UBE2L6, MME, IQGAP, SLC7A7, and PLG played a key role in regulating the incidence of DN. Besides, we also identified 1 up-regulated gene (PIK3C2B) and 39 down-regulated genes (POLR2G, DDB1, and ZNF230, etc.) in the methylated data of Glom specific genes. In the Tub specific expressed genes, we identified two hypo-methylated genes (PPARA and GLS). Tub mainly caused abnormal energy metabolism, and Glom caused the changes in cell connections and histone modification. By analyzing differentially methylated sites and tissue-specific expressed genes, we found the change of methylated status about the core regulating genes may be a potential factor in the pathogenesis of DN.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
高大凌寒应助嵇翩跹采纳,获得30
刚刚
桐桐应助应樱采纳,获得10
刚刚
路哈哈完成签到,获得积分10
刚刚
李健的小迷弟应助谁谁采纳,获得10
刚刚
1秒前
1秒前
orixero应助将将采纳,获得10
1秒前
金刚经应助香蕉海之采纳,获得10
1秒前
完美世界应助满意静丹采纳,获得10
1秒前
yemiao发布了新的文献求助10
1秒前
linus发布了新的文献求助10
2秒前
2秒前
tonia完成签到,获得积分10
6秒前
完美梨愁发布了新的文献求助10
6秒前
温连虎发布了新的文献求助10
6秒前
背完单词好睡觉完成签到 ,获得积分10
6秒前
月墨雪发布了新的文献求助10
7秒前
JIU夭发布了新的文献求助10
7秒前
8秒前
万能图书馆应助臭小子采纳,获得10
8秒前
chem is try完成签到,获得积分10
8秒前
8秒前
LH发布了新的文献求助10
9秒前
myth完成签到,获得积分10
10秒前
今后应助魔仙小废采纳,获得10
10秒前
10秒前
11秒前
jimmy发布了新的文献求助20
11秒前
Jolene66发布了新的文献求助10
12秒前
科目三应助小巧怀薇采纳,获得10
12秒前
12秒前
12秒前
在水一方应助。.。采纳,获得10
12秒前
曾经的又莲完成签到,获得积分10
13秒前
应樱发布了新的文献求助10
14秒前
家嵩发布了新的文献求助10
15秒前
Owen应助专注的映萱采纳,获得10
15秒前
超级碧曼完成签到,获得积分20
17秒前
18秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
Idoxuridine 260
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3194546
求助须知:如何正确求助?哪些是违规求助? 2843443
关于积分的说明 8045113
捐赠科研通 2507901
什么是DOI,文献DOI怎么找? 1340273
科研通“疑难数据库(出版商)”最低求助积分说明 638909
邀请新用户注册赠送积分活动 607780