Specific expression network analysis of diabetic nephropathy kidney tissue revealed key methylated sites

小桶 表观遗传学 基因 生物 遗传学 DNA甲基化 发病机制 基因表达 计算生物学 免疫学 转录组
作者
Yanzhe Wang,Wenwei Xu,Dingyu Zhu,Nan Zhang,Yonglan Wang,Miao Ding,Xinmiao Xie,Linlin Sun,Xiaoxia Wang
出处
期刊:Journal of Cellular Physiology [Wiley]
卷期号:233 (10): 7139-7147 被引量:23
标识
DOI:10.1002/jcp.26638
摘要

Diabetic nephropathy (DN) is one of the most common and serious complication in diabetes patients. However, the evidences of gene regulation mechanism and epigenetic modification with DN remain unclear. Therefore, it is necessary to search regulating genes for early diagnosis on DN. We identified tissue specific genes through mining the gene expression omnibus (GEO) public database, enriched function by gene ontology (GO), and kyoto encyclopedia of genes and genomes (KEGG) analysis, and further compared tissue-specific network. Meanwhile, combining with differentially methylated sites, we explored the association epigenetic modification with the pathogenesis of DN. Glomeruli (Glom) may be the main tissue of signal recognition and tubulointerstitium (Tub) is mainly associated with energy metabolism in the occurrence of DN. By comparing tissue-specific networks between Glom and Tub, we screened 319 genes, which played an important role in multiple tissue on kidney. Among them, ANXA2, UBE2L6, MME, IQGAP, SLC7A7, and PLG played a key role in regulating the incidence of DN. Besides, we also identified 1 up-regulated gene (PIK3C2B) and 39 down-regulated genes (POLR2G, DDB1, and ZNF230, etc.) in the methylated data of Glom specific genes. In the Tub specific expressed genes, we identified two hypo-methylated genes (PPARA and GLS). Tub mainly caused abnormal energy metabolism, and Glom caused the changes in cell connections and histone modification. By analyzing differentially methylated sites and tissue-specific expressed genes, we found the change of methylated status about the core regulating genes may be a potential factor in the pathogenesis of DN.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
1秒前
1秒前
2秒前
小蘑菇应助JELLY采纳,获得10
3秒前
Orange应助大鸡腿采纳,获得10
3秒前
蔺半山发布了新的文献求助10
3秒前
3秒前
GedeWang发布了新的文献求助10
5秒前
星辰大海应助逢投必中采纳,获得50
5秒前
5秒前
6秒前
6秒前
深情安青应助易安采纳,获得10
6秒前
7秒前
李爱国应助你拿你采纳,获得10
7秒前
不安青牛应助wang采纳,获得10
7秒前
领导范儿应助雨林采纳,获得10
7秒前
lytyl发布了新的文献求助30
7秒前
lytyl发布了新的文献求助30
8秒前
lytyl发布了新的文献求助10
8秒前
CodeCraft应助Hiraeth采纳,获得10
9秒前
竹音发布了新的文献求助10
10秒前
玩笑完成签到 ,获得积分10
10秒前
11秒前
热心的皮皮虾完成签到,获得积分10
11秒前
oyc发布了新的文献求助10
11秒前
上官若男应助luoliping采纳,获得10
12秒前
扶桑发布了新的文献求助10
13秒前
1+1应助缓慢太君采纳,获得10
13秒前
bkagyin应助wmlsdym采纳,获得10
13秒前
小蘑菇应助Puokn采纳,获得10
13秒前
Lucas应助sen123采纳,获得10
13秒前
13秒前
14秒前
14秒前
14秒前
15秒前
完美世界应助蔺半山采纳,获得10
16秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Write Like a Chemist: A Guide and Resource (第二版) 600
Mixed-anion Compounds 600
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Earth System Geophysics 500
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Geochemistry, 2nd Edition 地球化学经典教科书第二版 401
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3199844
求助须知:如何正确求助?哪些是违规求助? 2849134
关于积分的说明 8068932
捐赠科研通 2513326
什么是DOI,文献DOI怎么找? 1346110
科研通“疑难数据库(出版商)”最低求助积分说明 640167
邀请新用户注册赠送积分活动 609948