A Nomogram Based on the Characteristics of Metastatic Lymph Nodes to Predict Papillary Thyroid Carcinoma Recurrence

列线图 医学 甲状腺癌 危险分层 内科学 肿瘤科 多元分析 单变量 淋巴结 转移 多元统计 放射科 甲状腺 癌症 数学 统计
作者
Jianyong Lei,Jinjing Zhong,Zhihui Li,Tao Wei,Rixiang Gong,Jingqiang Zhu
出处
期刊:Thyroid [Mary Ann Liebert, Inc.]
卷期号:28 (3): 301-310 被引量:37
标识
DOI:10.1089/thy.2017.0422
摘要

The extent of metastatic lymph node (LN) invasion was not considered in the postoperative stratification of the recurrence risk of papillary thyroid carcinoma (PTC) in the 2015 American Thyroid Association (ATA) guidelines, and the recommended risk stratification cannot be applied to individuals. A nomogram based on these risk factors was developed based on the risk factors to predict individual recurrence risk.Data from 1788 PTC patients at the West China Hospital and 306 cases from the Shang Jin Nan Fu Hospital between August 2013 and July 2015 were included in this study. The 1788 cases were randomized into two groups-the training set (896 cases) and the testing set (896 cases)-and 306 cases were used as the external evaluation set.Univariate and multivariate analyses identified the following independent prognostic factors associated with recurrence in the three independent sets and the combined set (p < 0.01): LN invasion in the capsule or organ, more than five metastatic LNs, and a largest metastatic LN diameter >3 cm. Importantly, PTC patients showed significantly different recurrence rates depending on the extent of LN invasion in the three sets and in the combined set (p < 0.001). The nomogram was developed based on the risk factors in the training set and was validated in the independent testing and validation sets.The largest LN metastasis diameter, number of metastatic LNs, and the extent of extranodal invasion had significant prognostic value for predicting the risk of recurrence. Based on the characteristics of the thyroidal PTC lesion and metastatic LNs, the nomogram showed good prediction of recurrence in individual PTC patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
后会无期完成签到,获得积分10
1秒前
炒鸡小将发布了新的文献求助10
1秒前
1秒前
法外狂徒唐老鸭完成签到 ,获得积分10
2秒前
香蕉觅云应助maying0318采纳,获得10
3秒前
3秒前
无花果应助碧蓝碧凡采纳,获得10
4秒前
_hhhjhhh完成签到,获得积分10
4秒前
Leo完成签到,获得积分10
5秒前
6秒前
淘气科研发布了新的文献求助10
6秒前
小徐801完成签到,获得积分10
6秒前
7秒前
7秒前
wwk完成签到,获得积分10
7秒前
光亮不平完成签到,获得积分10
8秒前
llwxx完成签到,获得积分10
8秒前
梁大海发布了新的文献求助10
8秒前
甜蜜的楷瑞应助_hhhjhhh采纳,获得10
9秒前
諵十一完成签到,获得积分10
9秒前
zqingqing完成签到,获得积分10
10秒前
yize完成签到,获得积分10
11秒前
12秒前
12秒前
崔悦欣发布了新的文献求助10
12秒前
谨慎的擎宇完成签到,获得积分10
13秒前
Thomas完成签到,获得积分10
14秒前
小白鞋完成签到 ,获得积分10
14秒前
maying0318发布了新的文献求助10
16秒前
宣以晴完成签到,获得积分10
16秒前
Nnn完成签到,获得积分10
17秒前
baby完成签到,获得积分10
20秒前
123完成签到,获得积分10
20秒前
21秒前
学术牛马完成签到,获得积分10
21秒前
sl发布了新的文献求助10
23秒前
完美的鹤完成签到,获得积分10
24秒前
hky完成签到,获得积分10
25秒前
TTTHANKS完成签到 ,获得积分10
26秒前
WW完成签到,获得积分10
26秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038426
求助须知:如何正确求助?哪些是违规求助? 3576119
关于积分的说明 11374556
捐赠科研通 3305834
什么是DOI,文献DOI怎么找? 1819339
邀请新用户注册赠送积分活动 892678
科研通“疑难数据库(出版商)”最低求助积分说明 815029