医学
器官功能障碍
败血症
免疫功能障碍
炎症
内皮功能障碍
重编程
免疫系统
生物信息学
神经科学
重症监护医学
免疫学
内科学
细胞
生物
遗传学
作者
Rachel Pool,Hernando Gómez,John A. Kellum
标识
DOI:10.1016/j.ccc.2017.08.003
摘要
Sepsis-associated organ dysfunction involves multiple responses to inflammation, including endothelial and microvascular dysfunction, immune and autonomic dysregulation, and cellular metabolic reprogramming. The effect of targeting these mechanistic pathways on short- and long-term outcomes depends highly on the timing of therapeutic intervention. Furthermore, there is a need to understand the adaptive or maladaptive character of these mechanisms, to discover phase-specific biomarkers to guide therapy, and to conceptualize these mechanisms in terms of resistance and tolerance.
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