Multifunctional AIEgens: Ready Synthesis, Tunable Emission, Mechanochromism, Mitochondrial, and Bacterial Imaging

Abstract Luminogens with aggregation‐induced emission characteristics (AIEgens) are intriguing due to its rapid expansion in various high‐tech applications. However, there is still in high demand on the development of novel AIEgens with easy preparation and functionalization, stable structures, tunable emissions, and high quantum efficiency. In this contribution, three AIEgens based on diphenyl isoquinolinium (IQ) derivatives are reported. They can be facilely synthesized and possess high structural stability, favorable visible light excitation, large Stokes shifts, high quantum yields, tunable colors, and sufficient two‐photon absorption of near‐infrared light. Importantly, they exhibit multifunctionalities. They exhibit mechanochromic property, making them capable to be applied for rewritable papers. They can also be applied in mitochondrial imaging with high specificity, cell permeability, brightness, biocompatibility, and photostability. They are promising for the applications in evaluation of mitochondrial membrane potential and image‐guided cancer cell ablation. Last, they are able to stain bacteria in a wash‐free manner. All these intriguing results suggest such readily accessible and multifunctional diphenyl IQ‐based AIEgens provide a new platform for construction of advanced materials for practical applications.