旁侵犯
医学
背景(考古学)
皮肤癌
疾病
阶段(地层学)
基底细胞
肿瘤科
入射(几何)
专家意见
流行病学
内科学
癌症
重症监护医学
病理
皮肤病科
生物
古生物学
物理
光学
作者
Soodeh Kabir,Chrysalyne D. Schmults,Emily S. Ruiz
出处
期刊:International journal of cancer management
[Kowsar Medical Institute]
日期:2018-01-29
卷期号:11 (1)
被引量:13
摘要
Context: Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer and its incidence continues to rise worldwide. While the majority of CSCCs have excellent prognosis, a subset have the propensity to cause poor outcomes. Evidence Acquisition: A thorough Pubmed search was done and a collection of CSCC-relevant articles were selected based on the expert opinion. Results: A number of high-risk factors have been identified including perineural invasion (PNI), desmoplastic growth pattern, poor differentiation, high risk location and large diameter. Various staging systems have been developed based on these high-risk factors. Radiologic imaging is important for high-stage tumors and is likely associated with more aggressive management. Conclusions: Although surgical management is the gold standard, newer therapies such as programmed cell death protein-1 (PD-1) inhibitors show promise for locally advanced or metastatic disease. Despite advances in treatment, early diagnosis and prevention of CSCC is still the most important measure to ensure good outcomes.
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