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Wound healing activity of gamma-aminobutyric Acid (GABA) in rats.

伤口愈合 肉芽组织 成纤维细胞 碱性成纤维细胞生长因子 γ-氨基丁酸 细胞外基质 免疫染色 药理学 炎症 细胞生长 表皮生长因子 生长因子 化学 生物 病理 医学 生物化学 免疫学 免疫组织化学 体外 受体
作者
Dongoh Han,Hee-Young Kim,Hyejung Lee,Insop Shim,Dae–Hyun Hahm
出处
期刊:PubMed 卷期号:17 (10): 1661-9 被引量:92
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Gamma-aminobutyric acid (GABA) is a non-protein amino acid. It is well known for its role as an inhibitory neurotransmitter of developing and operating nervous systems in brains. In this study, a novel function of GABA in the healing process of cutaneous wounds was presented regarding anti-inflammation and fibroblast cell proliferation. The cell proliferation activity of GABA was verified through an MTT assay using murine fibroblast NIH3T3 cells. It was observed that GABA significantly inhibited the mRNA expression of iNOS, IL-1beta, and TNF-alpha, in LPS-stimulated RAW 264.7 cells. To evaluate in vivo activity of GABA in wound healing, excisional open wounds were made on the dorsal sides of Sprague-Dawley rats under anesthesia, and the healing of the wounds was apparently assessed. The molecular aspects of the healing process were also investigated by hematoxylineosin staining of the healed skin, displaying the degrees of reepithelialization and linear alignment of the granulation tissue, and immunostaining and RT-PCR analyses of fibroblast growth factor and platelet-derived growth factor, implying extracellular matrix synthesis and remodeling of the skin. The GABA treatment was effective to accelerate the healing process by suppressing inflammation and stimulating reepithelialization, compared with the epidermal growth factor treatment. The healing effect of GABA was remarkable at the early stage of wound healing, which resulted in significant reduction of the whole healing period.

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