Early and Supernormal Vascular Aging

医学 危险系数 动脉硬化 脉冲波速 内科学 队列 心脏病学 队列研究 比例危险模型 置信区间 血压
作者
Rosa Maria Bruno,Peter M. Nilsson,Gunnar Engström,Benjamin Nilsson Wadström,Jean Philippe Empana,Pierre Boutouyrie,Stéphane Laurent
出处
期刊:Hypertension [Lippincott Williams & Wilkins]
卷期号:76 (5): 1616-1624 被引量:90
标识
DOI:10.1161/hypertensionaha.120.14971
摘要

Pulse wave velocity is an established marker of early vascular aging but may also help identifying individuals with supernormal vascular aging. We tested the hypothesis that individuals with the largest difference (Δ-age) between chronological and vascular age show the lowest rate of cardiovascular events and may thus be defined as supernormal vascular aging. Vascular age was defined as the predicted age in the best fitting multivariable regression model including classical risk factors and treatment and pulse wave velocity, in a subset of the Reference Values for Arterial Stiffness Collaboration Database (n=3347). Δ-age was then calculated as chronological age minus vascular age, and the 10th and 90th percentiles were used to define early (Δ-age<−5.7 years), normal (Δ-age −5.7 to 6.8 years) and supernormal vascular aging (Δ-age>6.8 years). The risk for fatal and nonfatal cardiovascular events associated with vascular aging categories was investigated in the Malmö Diet and Cancer Study cohort (n=2642). In the Malmö Diet and Cancer Study Cohort (6.6-year follow-up, 286 events), Δ-age was significantly ( P <0.01) and inversely associated with cardiovascular events. Compared with normal vascular aging, supernormal vascular aging had lower risk (hazard ratio, 0.59 [95% CI, 0.41–0.85]), whereas early vascular aging had higher risk (hazard ratio, 2.70 [95% CI, 1.55–4.70]) of cardiovascular events, in particular coronary events. There was no significant association with all-cause mortality. This study represents the first validation of the clinical significance of the supernormal vascular aging concept, based on prospective data. Its further characterization may help discovering novel protective molecular pathways and providing preventive strategies for successful vascular aging.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
刚刚
Deify完成签到,获得积分10
1秒前
1秒前
拼尽全力发布了新的文献求助10
2秒前
Jasper应助溜达鸡采纳,获得10
4秒前
脑洞疼应助木子李采纳,获得30
5秒前
5秒前
7秒前
8秒前
Etiquette完成签到 ,获得积分10
9秒前
10秒前
精明的沅应助realtimes采纳,获得10
12秒前
14秒前
15秒前
木子李发布了新的文献求助30
18秒前
汉堡包应助dasdwdasd采纳,获得10
18秒前
卜懂得发布了新的文献求助10
19秒前
20秒前
Orange应助梅伊斯采纳,获得10
21秒前
MK完成签到,获得积分10
22秒前
大模型应助科研通管家采纳,获得10
22秒前
香蕉觅云应助科研通管家采纳,获得10
22秒前
22秒前
22秒前
22秒前
22秒前
22秒前
yar应助科研通管家采纳,获得10
22秒前
cindy发布了新的文献求助10
26秒前
gar发布了新的文献求助10
27秒前
老迟到的金鱼应助dentistx采纳,获得10
28秒前
29秒前
dasdwdasd完成签到,获得积分20
30秒前
小巧的牛排完成签到 ,获得积分10
31秒前
ZGZ123发布了新的文献求助15
32秒前
努力哥完成签到,获得积分10
32秒前
34秒前
dasdwdasd发布了新的文献求助10
34秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975375
求助须知:如何正确求助?哪些是违规求助? 3519700
关于积分的说明 11199305
捐赠科研通 3256034
什么是DOI,文献DOI怎么找? 1798049
邀请新用户注册赠送积分活动 877386
科研通“疑难数据库(出版商)”最低求助积分说明 806305