Anticancer mechanism and application of curcumin analog EF24

Curcumin is a polyphenol pigment product from the rhizome of curcumin longa. It is associated with numerous therapeutic benefits, including antioxidant, anti-inflammatory and anticancer activities. Research shows that EF24 is a curcumin analog that can induce tumor cell apoptosis, arrest cell cycle, inhibit cell invasion and metastasis and has synergistic effect of combined antitumor agents. EF24 has improved anticancer activity and bioavailability against various cancer cell lines over curcumin without increased toxicity. EF24 would have great potential to be used as a useful therapeutic agent for the treatment of various types of cancer. Key words: Antineoplastic agents; Curcumin; EF24