Effect of double use of gonadotropin-releasing hormone antagonist after premature luteinizing hormone surge during controlled ovarian hyperstimulation cycles

Objective To discuss the impact of premature luteinizing hormone (LH) surge on the follicle development and embryo quality during controlled ovarian hyperstimulation (COH). Methods The number of retrieved oocytes and embryo quality in two different COH cycles on the same patient were analyzed. Results The impact of premature LH surge during COH cycles was not significantly different on the follicle development and embryo quality after the double-dosegonadotropin-releasing hormone(GnRH) antagonist administration. Conclusion A double-dose of GnRH-antagonist administration could decrease the level of single premature LH surge to safe range, which might rescue this COH cycle and get high-quality embryos. Key words: Gonadotropin-releasing hormone (GnRH) antagonist protocol; Premature luteinizing hormone (LH) surge; Embryo quality