Multivariate analysis of chondrosarcoma prognosis

医学 软骨肉瘤 阶段(地层学) 多元分析 单变量分析 精确检验 回顾性队列研究 比例危险模型 病态的 外科 对数秩检验 生存分析 转移 内科学 癌症 古生物学 生物
作者
Zhengming Yang,Huimin Tao,Jiakai Zhang,Zhaoming Ye,Weixu Li,Nong Lin,Disheng Yang
出处
期刊:Chinese Journal of Orthopaedics [Chinese Medical Association]
卷期号:32 (11): 1020-1026
标识
DOI:10.3760/cma.j.issn.0253-2352.2012.11.007
摘要

Objective To screen possible factors affecting prognosis of chondrosarcoma.Methods A total of 37 patients with chondrosarcoma,who had undergone surgical treatment from December 2005 to March 2008 in our hospital and had complete follow-up data and definitive pathological diagnosis,were enrolled in this retrospective study.There were 16 males and 21 females,ageing from eleven to eighty-four years (average,42.8 years).The univariate analysis of survival rate was performed with Kaplan-Meier method and tested with the Log-rank test.Chi-squared test or Fisher's exact test were used to analyze numeration data,and then the significant indexes after univariate analysis were performed multivariate analysis with COX regression model to screen the independent factors affecting prognosis.On the basis of literatures,8factors including gender,age,duration of disease,tumor site,Enneking stage,surgical approach,distant metastasis and local recurrence were analyzed.Results Statistical significance was found in Enneking stage,surgical approach and distant metastasis,which indicated that they were related to survival rate 3years after surgery.However,gender,age,duration of disease,tumor site,and local recurrence had no significant correlation with prognosis.After multivariate analysis of Enneking stage,surgical approach,distant metastasis,the results showed that Enneking stage and surgical procedure were the independent prognostic factors,while distant metastasis was not an independent prognostic factor.Conclusion Enneking stage and surgical approach are the independent prognostic factors for chondrosarcoma,which can be used to evaluate prognosis of chondrosarcoma. Key words: Chondrosarcoma; Prognosis; Retrospective studies
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