Residential greenness associated with lower serum uric acid levels and hyperuricemia prevalence in a large Chinese rural population

高尿酸血症 四分位间距 医学 尿酸 置信区间 归一化差异植被指数 逻辑回归 人口学 人口 内科学 环境卫生 优势比 生态学 生物 叶面积指数 社会学
作者
Xiaokang Dong,Xiaotian Liu,Lulu Zhang,Ruiying Li,Runqi Tu,Jian Hou,Zhenxing Mao,Wenqian Huo,Yuming Guo,Shanshan Li,Gongbo Chen,Chongjian Wang
出处
期刊:Science of The Total Environment [Elsevier BV]
卷期号:770: 145300-145300 被引量:22
标识
DOI:10.1016/j.scitotenv.2021.145300
摘要

The association between residential greenness and hyperuricemia remains unclear, especially in developing countries. The current study aimed to explore the associations between residential greenness and both serum uric acid (SUA) levels and hyperuricemia in a Chinese rural population and to examine potential pathways of these associations. In this cross-sectional study, 38,721 rural residents were recruited from the baseline survey of the Henan Rural Cohort study in 2015–2017. Two satellite-derived vegetation indices, i.e., the normalized difference vegetation index (NDVI) and the enhanced vegetation index (EVI), were used to estimate residential greenness. Air pollution was determined by two proxies: particulate matter with aerodynamic diameter ≤ 2.5 μm (PM2.5) and nitrogen dioxide (NO2). Hyperuricemia was defined as SUA levels of >417 μmol/L and > 357 μmol/L for men and women, respectively. Multivariable-adjusted linear regression and logistic regression models were applied to investigate the associations of greenness with SUA and hyperuricemia, and mediation analyses were used to explore possible mechanisms underlying the associations. An interquartile range (IQR) increase in both EVI and NDVI in the 500 m buffer was significantly associated with reductions in SUA levels of −7.23 μmol/L (95% confidence interval (CI): −8.96, −5.50) and -4.38 μmol/L (95% CI: −5.93, −2.83), respectively. The same increases in EVI500-m and NDVI500-m were associated with 13.8% (95% CI: 5.8%, 21.2%) and 13.0% (95% CI: 5.6%, 19.8%) lower hyperuricemia prevalence, respectively. These associations were stronger in older people (age ≥ 65), men or participants with higher averaged monthly income. The associations were partly mediated by physical activity and BMI, while no mediation effect was observed for air pollution. Higher levels of residential greenness were significantly associated with lower SUA levels and hyperuricemia prevalence in the Chinese rural population. BMI and physical activity may play important mediating roles in the associations.
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