Prostate-specific Membrane Antigen Positron Emission Tomography–guided Radiotherapy

Radiotherapy has curative potential for patients with newly diagnosed localized prostate cancer and biochemical recurrence after radical prostatectomy, and can offer durable treatment responses for patients with oligometastatic disease. The success of radiotherapy in these settings relies on an accurate understanding of the extent of disease that is present and the precise anatomic localization of sites of disease. In this mini review, we provide an overview of recent data evaluating the role of positron emission tomography for assessing prostate-specific membrane antigen distribution in guiding radiotherapy in these settings. PATIENT SUMMARY: This mini review examines current evidence for the use of prostate-specific membrane antigen positron emission tomography/computed tomography to guide radiotherapy for patients with newly diagnosed localized prostate cancer, those with recurrences after radical prostatectomy, and those with oligometastatic disease.