光催化
半胺
化学
氟
二苯甲酮
亲核细胞
催化作用
戒指(化学)
组合化学
光化学
有机化学
光催化
作者
Ming‐Ming Wang,Jérôme Waser
标识
DOI:10.1002/anie.202007864
摘要
Abstract We report an oxidative ring‐opening strategy to transform cyclopropylamides and cyclobutylamides into fluorinated imines. The imines can be isolated in their more stable hemiaminal form, with the fluorine atom installed selectively at the γ or δ position. Both inexpensive benzophenone with UVA light or organic and inorganic dyes with blue light could be used as photoredox catalysts to promote this process. Various fluorinated amines were then obtained by nucleophilic attack on the hemiaminals in one pot, giving access to a broad range of useful building blocks for medicinal chemistry.
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