白色念珠菌
生物膜
体内
白色体
微生物学
体外
抗菌剂
化学
生物
细菌
生物化学
遗传学
生物技术
作者
M. L. He,Jiangwei Duan,Jialu Xu,Mingyu Ma,Bao Chai,Guangyuan He,Lu Gan,Qian Zhang,Xiaoru Duan,Xinpei Lu,Hongxiang Chen
标识
DOI:10.1002/ppap.201900068
摘要
Abstract Fungal infections induced by Candida albicans have increased worldwide due to emerging resistance to antifungal agents, which is largely caused by biofilm formation. Thus, a new and effective antimicrobial strategy is urgently required in treatment of C. albicans biofilm‐associated infections. In this study, the inactivation effects of cold plasma treatment for C. albicans biofilm are assessed in vitro and in vivo. In vitro studies indicate that C. albicans in suspension and the C. albicans biofilm are inactivated significantly by plasma treatment. In vivo studies indicate that plasma treatment achieves the best antifungal effect with an optimal dose (4 min in this case), as excessive plasma treatment damages the normal tissues and thus induces aggravation of infection compared to the 4‐min group.
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