活性氧
化学
败血症
催化作用
过氧化氢酶
抗氧化剂
促炎细胞因子
超氧化物歧化酶
酶
谷胱甘肽过氧化物酶
活性氮物种
生物化学
组合化学
炎症
免疫学
生物
作者
Fangfang Cao,Zongqing Lu,Yawen You,Lirong Zheng,Jinsong Ren,Xiaogang Qu
标识
DOI:10.1002/ange.201912182
摘要
Abstract Sepsis, characterized by immoderate production of multiple reactive oxygen and nitrogen species (RONS), causes high morbidity and mortality. Despite progress made with nanozymes, efficient antioxidant therapy to eliminate these RONS remains challenging, owing largely to the specificity and low activity of exploited nanozymes. Herein, an enzyme‐mimicking single‐atom catalyst, Co/PMCS, features atomically dispersed coordinatively unsaturated active Co‐porphyrin centers, which can rapidly obliterate multiple RONS to alleviate sepsis. Co/PMCS can eliminate O 2 .− and H 2 O 2 by mimicking superoxide dismutase, catalase, and glutathione peroxidase, while removing . OH via the oxidative‐reduction cycle, with markedly higher activity than nanozymes. It can also scavenge . NO through formation of a nitrosyl–metal complex. Eventually, it can reduce proinflammatory cytokine levels, protect organs from damage, and confer a distinct survival advantage to the infected sepsis mice.
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