对映选择合成
试剂
恶唑啉
化学
位阻效应
催化作用
电泳剂
钯
功能群
组合化学
配体(生物化学)
有机化学
手性配体
生物化学
受体
聚合物
作者
Xiaonan Li,Xiaoxu Qi,Chuanqi Hou,Pinhong Chen,Guosheng Liu
标识
DOI:10.1002/anie.202006757
摘要
Abstract The first Pd‐catalyzed enantioselective azidation of unactivated alkenes has been established by using readily accessible 1‐azido‐1,2‐benziodoxol‐3(1 H )‐one (ABX) as an azidating reagent, which affords a wide variety of structurally diverse 3‐N 3 ‐substituted piperidines in good yields with excellent enantioselectivity. The reaction features good functional‐group compatibility and mild reaction conditions. Notably, both an electrophilic azidating reagent and the sterically bulky chiral pyridinyl‐oxazoline (Pyox) ligand are crucial to the successful reaction.
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