甲基转移酶
不对称二甲基精氨酸
肾
糖尿病肾病
氧化应激
精氨酸
甲基化
蛋白质精氨酸甲基转移酶5
生物
医学
生物化学
内科学
DNA
氨基酸
作者
Chunyun Zhang,Shougang Zhuang
出处
期刊:Clinical Science
[Portland Press]
日期:2020-08-01
卷期号:134 (15): 2037-2051
被引量:7
摘要
Abstract The methylation of arginine residues by protein arginine methyltransferases (PRMTs) is a crucial post-translational modification for many biological processes, including DNA repair, RNA processing, and transduction of intra- and extracellular signaling. Previous studies have reported that PRMTs are extensively involved in various pathologic states, including cancer, inflammation, and oxidative stress reaction. However, the role of PRMTs has not been well described in kidney diseases. Recent studies have shown that aberrant function of PRMTs and its metabolic products—symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA)—are involved in several renal pathological processes, including renal fibrosis, acute kidney injury (AKI), diabetic nephropathy (DN), hypertension, graft rejection and renal tumors. We aim in this review to elucidate the possible roles of PRMTs in normal renal function and various kidney diseases.
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