成对比较
计算机科学
简编
药品
集合(抽象数据类型)
人工智能
机器学习
数据挖掘
医学
药理学
历史
考古
程序设计语言
作者
Aleksandr Ianevski,Anil K Giri,Prson Gautam,Alexander Kononov,Swapnil Potdar,Jani Saarela,Krister Wennerberg,Tero Aittokallio
标识
DOI:10.1038/s42256-019-0122-4
摘要
High-throughput drug combination screening provides a systematic strategy to discover unexpected combinatorial synergies in pre-clinical cell models. However, phenotypic combinatorial screening with multi-dose matrix assays is experimentally expensive, especially when the aim is to identify selective combination synergies across a large panel of cell lines or patient samples. Here, we implement DECREASE, an efficient machine learning model that requires only a limited set of pairwise dose–response measurements for accurate prediction of drug combination synergy in a given sample. Using a compendium of 23,595 drug combination matrices tested in various cancer cell lines and malaria and Ebola infection models, we demonstrate how cost-effective experimental designs with DECREASE capture almost the same degree of information for synergy and antagonism detection as the fully measured dose–response matrices. Measuring only the matrix diagonal provides an accurate and practical option for combinatorial screening. The minimal-input web implementation enables applications of DECREASE to both pre-clinical and translational studies. Drug combinations are often an effective means of managing complex diseases, but understanding the synergies of drug combinations requires extensive resources. The authors developed an efficient machine learning model that requires only a limited set of pairwise dose–response measurements for the accurate prediction of synergistic and antagonistic drug combinations.
科研通智能强力驱动
Strongly Powered by AbleSci AI