The dynamic mechanical properties of Ti-6Al-4V alloy prepared by laser direct deposition (LDD) at different strain rates are of great significance for the application of LDD technology in the manufacture and repair of aero-engine parts. The quasi-static tensile test and dynamic compression test of Ti-6Al-4V alloy prepared by LDD (LDD-Ti-6Al-4V) were carried out under the quasi-static and high strain rate using INSTRON-5982 tensile test equipment and Split Hopkinson pressure bar (SHPB) equipment. The true stress–strain curve is obtained, which indicates that the LDD-Ti-6Al-4V has a strain rate strengthening effect. Moreover, the Johnson–Cook (J–C) constitutive model of LDD-Ti-6Al-4V was fitted based on experimental data, and the experimental process of SHPB was numerically simulated. The simulation results are basically the same as the experimental results, which proves the correctness of the J–C constitutive model of LDD-Ti-6Al-4V.