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Intraradiological pathology‐calibrated electrical impedance spectroscopy in the evaluation of excision‐required breast lesions

医学 活检 纤维腺瘤 放射科 乳腺癌 病理 外科病理学 导管内乳头状瘤 乳房成像 病态的 乳腺摄影术 癌症 内科学
作者
Reihane Mahdavi,Sajad Mehrvarz,Parisa Hoseinpour,Narges Yousefpour,Fereshteh Abbasvandi,Mahtab Tayebi,Hossein Ataee,Mohammad Parniani,Saeed Abdolhoseini,Fateme Hajighasemi,Zeinab Nourinejad,Fatemeh Shojaeian,Hadi Ghafari,Mohammad Saeed Nikshoar,Mohammad Abdolahad
出处
期刊:Medical Physics [Wiley]
卷期号:49 (4): 2746-2760 被引量:2
标识
DOI:10.1002/mp.15481
摘要

Evaluating a real-time complementary bioelectrical diagnostic device based on electrical impedance spectroscopy (EIS) for improving breast imaging-reporting and data system (BI-RADS) scoring accuracy, especially in high-risk or borderline breast diseases. The primary purpose is to characterize breast tumors based on their dielectric properties. Early detection of high-risk lesions and increasing the accuracy of tumor sampling and pathological diagnosis are secondary objectives of the study.The tumor detection probe (TDP) was first applied to the mouse model for electrical safety evaluations by electrical current measurement. Then it was utilized for characterization of 138 human palpable breast lesions that were to undergo core needle biopsy (CNB), vacuum-assisted biopsy (VAB), or fine needle aspiration (FNA) on the surgeon's requests. Impedance phase slope (IPS) in frequency ranges of 100- 500 kHz and impedance magnitude in f = 1 kHz were extracted as the classification parameters. Consistency of radiological and pathological declarations for the excisional recommendation was then compared with the IPS values.Considering pathological results as the gold standard, meaningful correlations between IPS and pathophysiological status of lesions recommended for excision (such as atypical ductal hyperplasia, papillary lesions, complex sclerosing adenosis, and fibroadenoma) were observed (p < 0.0001). These pathophysiological properties may include cell size, membrane permeability, packing density, adenosis, cytoplasm structure, etc. Benign breast lesions showed IPS values greater than 0, while high-risk proliferative, precancerous, or cancerous lesions had negative IPS values. Statistical analysis showed 95% sensitivity with area under the curve (AUC) equal to 0.92.Borderline breast diseases and high-risk lesions that should be excised according to standard guidelines can be diagnosed with TDP before any sampling process. It is an important outcome for high-risk lesions that are radiologically underestimated to BI-RADS3, specifically in younger patients with dense breast masses that present challenges in mammographic and sonographic evaluations. Also, the lowest IPS value detects the most pathologic portions of the tumor for increasing sampling accuracy in large tumors.Precise detection of high-risk breast masses, which may be declared BI-RADS3 instead of BI-RADS4a.
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