计算机科学
人工智能
深度学习
匹配(统计)
模式识别(心理学)
结构变异
对象(语法)
基因组
数学
基因
遗传学
生物
统计
作者
Kai Ye,Jiadong Lin,Songbo Wang,Peter A. Audano,Jacob I. Flores,Walter A. Kosters,Xiaofei Yang,Peng Jia,Tobias Marschall,Christine R. Beck
出处
期刊:Research Square - Research Square
日期:2022-01-31
被引量:2
标识
DOI:10.21203/rs.3.rs-1270846/v1
摘要
Abstract Complex structural variants (CSVs) encompass multiple breakpoints and are often missed or misinterpreted by state-of-the-art variant detection algorithms. We developed SVision, a deep-learning based multi-object recognition framework, to automatically detect and characterize CSVs from long-read data. SVision outperforms current variant callers at identifying internal structure of complex events and revealed 80 high-quality CSVs with 25 distinct structures from an individual genome. SVision directly detects CSVs without pattern matching against a database of known structures, allowing sensitive detection of both common and previously uncharacterized complex rearrangements.
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