噬菌体
受体
寄主(生物学)
生物
细胞生物学
重定目标
生物物理学
细菌
微生物学
化学
遗传学
大肠杆菌
基因
计算机科学
计算机视觉
作者
Mateo Seoane‐Blanco,Mark J. van Raaij,Meritxell Granell
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2020-12-10
卷期号:: 194-205
被引量:1
标识
DOI:10.1016/b978-0-12-814515-9.00152-1
摘要
Bacteriophages have specialized receptor binding proteins for initial, specific, but reversible, host cell wall recognition. Once a suitable host is found, the phage commits to infection by irreversible attachment via a secondary interaction. The structures of several of the receptor-binding proteins that mediate these interactions have been solved. They can be long and thin, forming tail fibers, or shorter and stubby, forming tailspikes. Tail fibers and tailspikes are mainly beta-structured, but structurally highly diverse. Mutation of bacteriophage receptor-binding domains may allow retargeting of phages to alternative host bacteria.
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