光老化
哈卡特
化学
生物利用度
成分
保健品
活性成分
固体脂质纳米粒
纳米颗粒
晒伤
透明质酸
食品科学
纳米技术
药物输送
药理学
生物化学
皮肤病科
材料科学
有机化学
医学
解剖
体外
作者
Jingjing Zhu,Xiaonan Huang,Tao Yang,Chuan‐He Tang,Shou‐Wei Yin,Xiao-Jiang Jia,Xiao‐Quan Yang
标识
DOI:10.1016/j.indcrop.2022.114521
摘要
Zein colloidal particles, which have generally regarded as safe (GRAS) status, have been routinely used in formulations of oral nutraceuticals but not in skin care products. Herein, we constructed for the first time zein-based topical vehicles to address skin photoaging. To this end, we fabricated a new type of eco-friendly nanoparticles by co-assembling zein with hyaluronic acid (HA), a cell-specific molecule, to encapsulate hydrophobic tetrahydrocurcumin (THC) with an aim to improve its cutaneous bioavailability. Impressively, the prepared nanoparticles could increase the solubility of THC in water by 72.84 times, and were stable at pH 4–10. In particular, the topical delivery systems were effective in UVB-induced cell and animal photoaging models, and were able to restore the accumulation of matrix metalloproteinase-1 (MMP-1) and inflammatory factors to the normal levels at the selected conditions. In addition, the biotransformation of THC in HaCaT cells was observed and clarified. This strategy may open up new promising avenues for developing innovative nanocosmetics containing anti-photoaging ingredient.
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