A Guide to the Non-Invasive Imaging Assessment of Cardiac Amyloidosis

Cardiac amyloidosis (CA) is a progressive infiltrative cardiomyopathy, historically considered rare but now increasingly recognized with advances in cardiac imaging. It is characterized by deposition of misfolded protein, either light chain (AL) or transthyretin (ATTR, wild-type or hereditary), within various cardiac chambers resulting in both systolic and diastolic heart failure and arrhythmias.1 The advent of therapies halting progression of disease emphasizes the need for an earlier diagnosis.