A multi center real world observation to evaluate the efficacy of cryotherapy versus local hyperthermia for the treatment of plane warts

Dermatologic TherapyVolume 35, Issue 5 e15403 ORIGINAL ARTICLE A multi center real world observation to evaluate the efficacy of cryotherapy versus local hyperthermia for the treatment of plane warts Sheng-Nan Zhao, Sheng-Nan Zhao Department of Dermatology, The First Hospital of China Medical University, Shenyang, China Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, China National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China National Engineering Research Center for Immunodermatoloigcal Theranostics, Shenyang, ChinaSearch for more papers by this authorWei Huo, Wei Huo Department of Dermatology, The First Hospital of China Medical University, Shenyang, China Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, China National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China National Engineering Research Center for Immunodermatoloigcal Theranostics, Shenyang, ChinaSearch for more papers by this authorQian An, Qian An Department of Dermatology, The First Hospital of China Medical University, Shenyang, China Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, China National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China National Engineering Research Center for Immunodermatoloigcal Theranostics, Shenyang, ChinaSearch for more papers by this authorTian-Wen Gao, Tian-Wen Gao Department of Dermatology, Xijing Hospital of Air Force Medical University, Xi'an, ChinaSearch for more papers by this authorZhi-Rong Yao, Zhi-Rong Yao Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, ChinaSearch for more papers by this authorJian-Zhong Zhang, Jian-Zhong Zhang orcid.org/0000-0002-5485-682X Dermatology, Peking University, Beijing, ChinaSearch for more papers by this authorXue-Jun Zhang, Xue-Jun Zhang orcid.org/0000-0001-6881-9504 Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaSearch for more papers by this authorHeng Gu, Heng Gu Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaSearch for more papers by this authorRi-Na Wu, Ri-Na Wu Department of Dermatology, Inner Mongolia Medical University, Hohhot, Inner Mongolia, ChinaSearch for more papers by this authorHong-Guang Lu, Hong-Guang Lu Dermatology, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaSearch for more papers by this authorXiu-Ping Han, Xiu-Ping Han Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, ChinaSearch for more papers by this authorFan-Qin Zeng, Fan-Qin Zeng Department of Dermatology, Sun Yat-sen Memorial Hospital of the Sun Yat-sen University, Guangzhou, ChinaSearch for more papers by this authorRong-Zhen An, Rong-Zhen An Department of Dermatology and Venerology, Affiliated Hospital of Binzhou Medical University, Binzhou, ChinaSearch for more papers by this authorLei Ma, Lei Ma Department of Dermatology and Venerology, Affiliated Hospital of Binzhou Medical University, Binzhou, ChinaSearch for more papers by this authorHong-Duo Chen, Hong-Duo Chen Department of Dermatology, The First Hospital of China Medical University, Shenyang, China Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, China National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China National Engineering Research Center for Immunodermatoloigcal Theranostics, Shenyang, ChinaSearch for more papers by this authorRui-Qun Qi, Corresponding Author Rui-Qun Qi [email protected] orcid.org/0000-0002-5856-4584 Department of Dermatology, The First Hospital of China Medical University, Shenyang, China Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, China National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China National Engineering Research Center for Immunodermatoloigcal Theranostics, Shenyang, China Correspondence Rui-Qun Qi, Department of Dermatology, The First Hospital of China Medical University, 155N Nanjing Street, Heping, Shenyang, Liaoning 110001, China. Email: [email protected] Xing-Hua Gao, Department of Dermatology, The First Hospital of China Medical University, 155N Nanjing Street, Heping, Shenyang, Liaoning 110001, China and National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China. Email: [email protected]Search for more papers by this authorXing-Hua Gao, Corresponding Author Xing-Hua Gao [email protected] orcid.org/0000-0001-8809-8564 Department of Dermatology, The First Hospital of China Medical University, Shenyang, China Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, China National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China National Engineering Research Center for Immunodermatoloigcal Theranostics, Shenyang, China Correspondence Rui-Qun Qi, Department of Dermatology, The First Hospital of China Medical University, 155N Nanjing Street, Heping, Shenyang, Liaoning 110001, China. Email: [email protected] Xing-Hua Gao, Department of Dermatology, The First Hospital of China Medical University, 155N Nanjing Street, Heping, Shenyang, Liaoning 110001, China and National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China. Email: [email protected]Search for more papers by this author Sheng-Nan Zhao, Sheng-Nan Zhao Department of Dermatology, The First Hospital of China Medical University, Shenyang, China Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, China National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China National Engineering Research Center for Immunodermatoloigcal Theranostics, Shenyang, ChinaSearch for more papers by this authorWei Huo, Wei Huo Department of Dermatology, The First Hospital of China Medical University, Shenyang, China Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, China National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China National Engineering Research Center for Immunodermatoloigcal Theranostics, Shenyang, ChinaSearch for more papers by this authorQian An, Qian An Department of Dermatology, The First Hospital of China Medical University, Shenyang, China Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, China National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China National Engineering Research Center for Immunodermatoloigcal Theranostics, Shenyang, ChinaSearch for more papers by this authorTian-Wen Gao, Tian-Wen Gao Department of Dermatology, Xijing Hospital of Air Force Medical University, Xi'an, ChinaSearch for more papers by this authorZhi-Rong Yao, Zhi-Rong Yao Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, ChinaSearch for more papers by this authorJian-Zhong Zhang, Jian-Zhong Zhang orcid.org/0000-0002-5485-682X Dermatology, Peking University, Beijing, ChinaSearch for more papers by this authorXue-Jun Zhang, Xue-Jun Zhang orcid.org/0000-0001-6881-9504 Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaSearch for more papers by this authorHeng Gu, Heng Gu Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaSearch for more papers by this authorRi-Na Wu, Ri-Na Wu Department of Dermatology, Inner Mongolia Medical University, Hohhot, Inner Mongolia, ChinaSearch for more papers by this authorHong-Guang Lu, Hong-Guang Lu Dermatology, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaSearch for more papers by this authorXiu-Ping Han, Xiu-Ping Han Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, ChinaSearch for more papers by this authorFan-Qin Zeng, Fan-Qin Zeng Department of Dermatology, Sun Yat-sen Memorial Hospital of the Sun Yat-sen University, Guangzhou, ChinaSearch for more papers by this authorRong-Zhen An, Rong-Zhen An Department of Dermatology and Venerology, Affiliated Hospital of Binzhou Medical University, Binzhou, ChinaSearch for more papers by this authorLei Ma, Lei Ma Department of Dermatology and Venerology, Affiliated Hospital of Binzhou Medical University, Binzhou, ChinaSearch for more papers by this authorHong-Duo Chen, Hong-Duo Chen Department of Dermatology, The First Hospital of China Medical University, Shenyang, China Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, China National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China National Engineering Research Center for Immunodermatoloigcal Theranostics, Shenyang, ChinaSearch for more papers by this authorRui-Qun Qi, Corresponding Author Rui-Qun Qi [email protected] orcid.org/0000-0002-5856-4584 Department of Dermatology, The First Hospital of China Medical University, Shenyang, China Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, China National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China National Engineering Research Center for Immunodermatoloigcal Theranostics, Shenyang, China Correspondence Rui-Qun Qi, Department of Dermatology, The First Hospital of China Medical University, 155N Nanjing Street, Heping, Shenyang, Liaoning 110001, China. Email: [email protected] Xing-Hua Gao, Department of Dermatology, The First Hospital of China Medical University, 155N Nanjing Street, Heping, Shenyang, Liaoning 110001, China and National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China. Email: [email protected]Search for more papers by this authorXing-Hua Gao, Corresponding Author Xing-Hua Gao [email protected] orcid.org/0000-0001-8809-8564 Department of Dermatology, The First Hospital of China Medical University, Shenyang, China Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, China National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China National Engineering Research Center for Immunodermatoloigcal Theranostics, Shenyang, China Correspondence Rui-Qun Qi, Department of Dermatology, The First Hospital of China Medical University, 155N Nanjing Street, Heping, Shenyang, Liaoning 110001, China. Email: [email protected] Xing-Hua Gao, Department of Dermatology, The First Hospital of China Medical University, 155N Nanjing Street, Heping, Shenyang, Liaoning 110001, China and National and Local Joint Engineering Research Centre of Immunodermatological Theranostics, Shenyang, China. Email: [email protected]Search for more papers by this author First published: 24 February 2022 https://doi.org/10.1111/dth.15403Citations: 1 Sheng-Nan Zhao and Wei Huo contributed equally to this article. Funding information: Programme for Innovative platform construction, Liaoning Science and Technology Bureau, Grant/Award Number: 2018225058; The National Science Foundation of China-Liaoning Joint Programme, Grant/Award Number: U1908206 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Most plane warts are recalcitrant to treatment. Both cryotherapy and local hyperthermia have been applied to treat plane warts. However, no direct comparative study on their respective efficacy and safety has ever been performed. To assess the efficacy and safety of local hyperthermia at 43 ± 1°C versus liquid nitrogen cryotherapy for plane warts. Sequential patients with plane warts entered the study, either receiving cryotherapy or local hyperthermia therapy at the discretion of the patients and the recommendations of consultants. Cryotherapy with liquid nitrogen was delivered in two sessions 2 weeks apart, while local hyperthermia was delivered on three consecutive days, plus two similar treatments 10 ± 3 days later. The temperature over the treated skin surface was set at 43 ± 1°C for 30 min in each session. The primary outcome was the clearance rates of the lesions 6 months after treatment. Among the 194 participants enrolled, 183 were included in the analysis at 6 months. Local hyperthermia and cryotherapy achieved clearance rates of 35.56% (48/135) and 31.25% (15/48), respectively (p = 0.724); recurrence rates of 16.67% (8/48) and 53.33% (8/15) (p = 0.01); and adverse events rates of 20.74% (28/135) and 83.33% (40/48), respectively (p < 0.001). Cryotherapy had a higher pain score (p < 0.001) and a longer healing time (p < 0.001). Local hyperthermia at 43°C and cryotherapy had similar efficacy for plane warts. Local hyperthermia had a safer profile than cryotherapy but it required more treatment visits during a treatment course. More patients preferred local hyperthermia due to its treatment friendly nature. CONFLICT OF INTEREST The authors report no conflict of interest. Open Research DATA AVAILABILITY STATEMENT We hope that the data will not be public. If researchers are interested in our study, they can contact us by email. We are very happy to give help. Citing Literature Supporting Information Filename Description dth15403-sup-0001-FigureS1.pdfPDF document, 2.3 MB Figure S1. Local hyperthermia device dth15403-sup-0002-Tables.docxWord 2007 document , 33.7 KB Table S1. Source of the 192 individuals with plane warts Table S2. Curative rate at of hyperthermia and cryotherapy at 6 months follow-up Table S3. Stepwise multiple logistic regression analysis in the local hyperthermia group Table S4. Stepwise multiple logistic regression analysis in the cryotherapy group Table S5. Partial response rates of hyperthermia and cryotherapy in the treatment of plane warts Table S6. Adverse effects of the two groups Table S7. Degree of pain during the treatment in two groups Table S8. Delays on work hours in two groups Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume35, Issue5May 2022e15403 RelatedInformation