透皮
姜黄素
材料科学
药品
自愈水凝胶
药理学
败血症
抗菌剂
壳聚糖
新生儿败血症
生物医学工程
纳米技术
医学
化学
有机化学
外科
高分子化学
作者
Min Qian,Di Ma,Xiaoqi Zhao,Wanxu Guo,Yunfeng Zhang
出处
期刊:Materials Express
[American Scientific Publishers]
日期:2021-07-01
卷期号:11 (7): 1101-1108
被引量:4
标识
DOI:10.1166/mex.2021.1893
摘要
Neonatal sepsis is a leading cause of neonatal mortality worldwide. Typically, intramuscular injections of gentamycin and vancomycin have been the preferred treatment for sepsis. The use of these drug molecules has many complications because of some side effects, proper dosage calculations, and harmless injection supply. In the present study, we developed new combinations of therapeutic drug molecules containing anti-inflammatory curcumin with bioactive antimicrobial peptides (AMP). We designed and developed a biocompatible and thermally responsive chitosan/polyacrylamide polymeric microneedle array to deliver AMP/curcumin nanoparticles (Nano-Cur) transdermally. The prepared drug-loaded microneedles were investigated for their chemical and morphological structure, in vitro insertion, and transdermal drug release. This investigation established that AMP/Nano-Cur-loaded microneedles have potential effects in sepsis treatment.
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