亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Kidney Transplantation in Small Children: Association Between Body Weight and Outcome—A Report From the ESPN/ERA-EDTA Registry

医学 危险系数 置信区间 移植 透析 肾功能 肾脏替代疗法 内科学 肾移植 比例危险模型 肾脏疾病 肾病科 外科 儿科 泌尿科
作者
Michael Böehm,Marjolein Bonthuis,Christoph Aufricht,Nina Battelino,Anna Bjerre,Viðar Ö. Eðvarðsson,Maria Herthelius,Holger Hubmann,Timo Jahnukainen,Huib de Jong,Guido F. Laube,Francesca Mattozzi,Е. А. Молчанова,Marina Muñoz,Aytül Noyan,Lars Pape,Nikoleta Printza,György Reusz,G. Roussey,Jacek Rubik,Brankica Spasojević,Tomáš Seeman,Nicholas Ware,Enrico Vidal,Jérôme Harambat,Kitty J. Jager,Jaap W. Groothoff
出处
期刊:Transplantation [Wolters Kluwer]
卷期号:106 (3): 607-614 被引量:5
标识
DOI:10.1097/tp.0000000000003771
摘要

Background. Many centers accept a minimum body weight of 10 kg as threshold for kidney transplantation (Tx) in children. As solid evidence for clinical outcomes in multinational studies is lacking, we evaluated practices and outcomes in European children weighing below 10 kg at Tx. Methods. Data were obtained from the European Society of Paediatric Nephrology/European Renal Association and European Dialysis and Transplant Association Registry on all children who started kidney replacement therapy at <2.5 y of age and received a Tx between 2000 and 2016. Weight at Tx was categorized (<10 versus ≥10 kg) and Cox regression analysis was used to evaluate its association with graft survival. Results. One hundred of the 601 children received a Tx below a weight of 10 kg during the study period. Primary renal disease groups were equal, but Tx <10 kg patients had lower pre-Tx weight gain per year (0.2 versus 2.1 kg; P < 0.001) and had a higher preemptive Tx rate (23% versus 7%; P < 0.001). No differences were found for posttransplant estimated glomerular filtration rates trajectories ( P = 0.23). The graft failure risk was higher in Tx <10 kg patients at 1 y (graft survival: 90% versus 95%; hazard ratio, 3.84; 95% confidence interval, 1.24-11.84), but not at 5 y (hazard ratio, 1.71; 95% confidence interval, 0.68-4.30). Conclusions. Despite a lower 1-y graft survival rate, graft function, and survival at 5 y were identical in Tx <10 kg patients when compared with Tx ≥10 kg patients. Our results suggest that early transplantation should be offered to a carefully selected group of patients weighing <10 kg.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
黑白完成签到 ,获得积分10
2分钟前
2分钟前
Qian完成签到 ,获得积分10
2分钟前
情怀应助Ying采纳,获得20
2分钟前
3分钟前
3分钟前
科研通AI5应助忧虑的安青采纳,获得10
3分钟前
juejue333完成签到,获得积分10
3分钟前
3分钟前
3分钟前
Ying发布了新的文献求助20
3分钟前
4分钟前
Betty发布了新的文献求助10
4分钟前
Betty完成签到,获得积分10
4分钟前
科目三应助科研通管家采纳,获得10
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
SciGPT应助科研通管家采纳,获得10
4分钟前
笨笨完成签到,获得积分10
5分钟前
5分钟前
5分钟前
思源应助嘿嘿嘿侦探社采纳,获得10
5分钟前
5分钟前
5分钟前
5分钟前
gyh发布了新的文献求助10
6分钟前
孤独的涵柳完成签到 ,获得积分10
6分钟前
6分钟前
gyh完成签到,获得积分20
6分钟前
6分钟前
科研通AI2S应助科研通管家采纳,获得30
6分钟前
Owen应助科研通管家采纳,获得10
6分钟前
科研通AI2S应助科研通管家采纳,获得10
6分钟前
7分钟前
7分钟前
7分钟前
搜集达人应助喜欢对你笑采纳,获得10
7分钟前
隐形曼青应助科研通管家采纳,获得10
8分钟前
科研通AI2S应助科研通管家采纳,获得10
8分钟前
老石完成签到 ,获得积分10
9分钟前
10分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968504
求助须知:如何正确求助?哪些是违规求助? 3513278
关于积分的说明 11167234
捐赠科研通 3248660
什么是DOI,文献DOI怎么找? 1794386
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804638