清脆的
核酸酶
计算生物学
基因组编辑
计算机科学
核酸
生物
核糖核酸
DNA
遗传学
基因
标识
DOI:10.3389/fcell.2022.834646
摘要
Abundant CRISPR-Cas systems in nature provide us with unlimited valuable resources to develop a variety of versatile tools, which are powerful weapons in biological discovery and disease treatment. Here, we systematically review the development of CRISPR-Cas based tools from DNA nuclease to RNA nuclease, from nuclease dependent-tools to nucleic acid recognition dependent-tools. Also, considering the limitations and challenges of current CRISPR-Cas based tools, we discuss the potential directions for development of novel CRISPR toolkits in the future.
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