机械转化
肿瘤微环境
机械生物学
转移
癌变
肿瘤进展
旁分泌信号
癌症研究
癌症
生物
神经科学
细胞生物学
医学
肿瘤细胞
内科学
受体
作者
Hanying Zhou,Meng Wang,Yixi Zhang,Qingqing Su,Zhengxin Xie,Xiangyan Chen,Ran Yan,Ping Li,Tingting Li,Xiang Qin,Hong Yang,Chunhui Wu,Fengming You,Shun Li,Yiyao Liu
摘要
Dynamic and heterogeneous interaction between tumor cells and the surrounding microenvironment fuels the occurrence, progression, invasion, and metastasis of solid tumors. In this process, the tumor microenvironment (TME) fractures cellular and matrix architecture normality through biochemical and mechanical means, abetting tumorigenesis and treatment resistance. Tumor cells sense and respond to the strength, direction, and duration of mechanical cues in the TME by various mechanotransduction pathways. However, far less understood is the comprehensive perspective of the functions and mechanisms of mechanotransduction. Due to the great therapeutic difficulties brought by the mechanical changes in the TME, emerging studies have focused on targeting the adverse mechanical factors in the TME to attenuate disease rather than conventionally targeting tumor cells themselves, which has been proven to be a potential therapeutic approach. In this review, we discussed the origins and roles of mechanical factors in the TME, cell sensing, mechano-biological coupling and signal transduction, in vitro construction of the tumor mechanical microenvironment, applications and clinical significance in the TME.
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