脂质体
囊性纤维化
炎症
酶
脱氧核糖核酸酶ⅰ
药物输送
药理学
药品
化学
医学
生物化学
免疫学
内科学
DNA
有机化学
基序列
作者
Lesly Carolina Penaloza Arias,David N. Huynh,Samuel Babity,Sylvie Marleau,Davide Brambilla
标识
DOI:10.1021/acs.molpharmaceut.2c00086
摘要
Drug delivery systems such as liposomes are widely used to stabilize and increase the plasma half-life of therapeutics. In this article, we have investigated two strategies to increase the half-life of deoxyribonuclease I, an FDA-approved enzyme used for the treatment of cystic fibrosis, and a potential candidate for the reduction of uncontrolled inflammation induced by neutrophil extracellular traps. We demonstrate that our optimized preparation procedure resulted in nanoparticles with improved plasma half-life and total exposure relative to native protein, while maintaining enzymatic activity.
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