Comparison of New Glucose-Lowering Drugs on the Risk of Pancreatitis in Type 2 Diabetes: A Network Meta-Analysis

医学 胰腺炎 内科学 2型糖尿病 糖尿病 荟萃分析 急性胰腺炎 重症监护医学 内分泌学
作者
Xuexue Zhang,Miaoran Wang,Xujie Wang,Zhengchuan Zhu,Wantong Zhang,Zhongyang Zhou,Wei Tang,Qiuyan Li
出处
期刊:Endocrine Practice [Elsevier BV]
卷期号:28 (3): 333-341 被引量:17
标识
DOI:10.1016/j.eprac.2021.12.007
摘要

Abstract

Objective

To explore whether new glucose-lowering drugs increase the risk of pancreatitis in individuals with type 2 diabetes. This present network meta-analysis aimed to investigate the risk of pancreatitis associated with the use of glucagon-like peptide-1 (GLP-1) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors in the treatment of type 2 diabetes mellitus.

Methods

PubMed, Web of Science, Embase, and the Cochrane Library were searched. The literature was published from the date of their inception to July 21, 2021, including placebo-controlled or head-to-head trials of 2 new glucose-lowering drugs. The relative ratio (RR) and 95% confidence interval (CI) were used to assess the risk of GLP-1 agonists and DPP-4 inhibitors for pancreatitis or pancreatic cancer among patients with type 2 diabetes.

Results

Seventeen studies were identified, covered 102 257 participants. The pooled results showed a neutral relationship between GLP-1 agonists and pancreatitis (overall RR, 0.96; 95% CI, 0.31-3.00) or pancreatic cancer (overall RR, 1.10; 95% CI, 0.31-4.10) compared with placebo. Meanwhile, DPP-4 inhibitors were not associated with the increased risk of pancreatitis (overall RR, 1.60; 95% CI, 0.25-11.00) or pancreatic cancer (overall RR, 0.79; 95% CI, 0.26-2.40). Among them, lixisenatide and saxagliptin may be the safest drugs compared with other drugs according to the ranking of probability. Sensitivity and subgroup analysis confirmed the stability of the core results.

Conclusion

The most obvious finding of this study is that GLP-1 agonists and DPP-4 inhibitors are safe with respect to the risk of pancreatitis and pancreatic cancer compared with placebo. This conclusion may provide useful evidence for correlated clinical researches.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科目三应助马士全采纳,获得10
3秒前
penny发布了新的文献求助10
4秒前
Juan应助重要的秋尽采纳,获得10
5秒前
量子星尘发布了新的文献求助10
5秒前
Jasper应助科研战士采纳,获得10
5秒前
houfei发布了新的文献求助10
5秒前
11秒前
11秒前
左左发布了新的文献求助10
11秒前
12秒前
研友_VZG7GZ应助路路采纳,获得10
12秒前
13秒前
14秒前
颖火虫发布了新的文献求助10
16秒前
mm发布了新的文献求助10
17秒前
Mipe完成签到,获得积分10
18秒前
澡雪发布了新的文献求助10
18秒前
钱多多完成签到,获得积分10
19秒前
21秒前
雪白砖家完成签到 ,获得积分10
21秒前
吴大语完成签到,获得积分10
21秒前
虚幻初之发布了新的文献求助10
23秒前
23秒前
24秒前
我是老大应助99采纳,获得10
25秒前
bias完成签到,获得积分10
25秒前
27秒前
27秒前
Anthony_潇发布了新的文献求助10
27秒前
27秒前
汉堡包应助mm采纳,获得10
29秒前
29秒前
an完成签到,获得积分10
30秒前
31秒前
梓歆发布了新的文献求助10
31秒前
Alan发布了新的文献求助10
31秒前
上官若男应助99采纳,获得10
31秒前
cyj发布了新的文献求助10
33秒前
33秒前
半糖发布了新的文献求助10
33秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975516
求助须知:如何正确求助?哪些是违规求助? 3519930
关于积分的说明 11200130
捐赠科研通 3256278
什么是DOI,文献DOI怎么找? 1798183
邀请新用户注册赠送积分活动 877425
科研通“疑难数据库(出版商)”最低求助积分说明 806320