Distal Convoluted Tubule

远曲小管 致密斑 吉特尔曼综合征 协同运输机 肾单位 重吸收 内分泌学 瞬时受体电位通道 内科学 顶膜 化学 平衡 醛固酮 细胞生物学 肾脏生理学 肾素-血管紧张素系统 生物 医学 受体 生物化学 血压 低镁血症 有机化学
作者
James A. McCormick,David H. Ellison
出处
期刊:Comprehensive Physiology [Wiley]
卷期号:: 45-98 被引量:91
标识
DOI:10.1002/cphy.c140002
摘要

The distal convoluted tubule (DCT) is a short nephron segment, interposed between the macula densa and collecting duct. Even though it is short, it plays a key role in regulating extracellular fluid volume and electrolyte homeostasis. DCT cells are rich in mitochondria, and possess the highest density of Na+/K+-ATPase along the nephron, where it is expressed on the highly amplified basolateral membranes. DCT cells are largely water impermeable, and reabsorb sodium and chloride across the apical membrane via electroneurtral pathways. Prominent among this is the thiazide-sensitive sodium chloride cotransporter, target of widely used diuretic drugs. These cells also play a key role in magnesium reabsorption, which occurs predominantly, via a transient receptor potential channel (TRPM6). Human genetic diseases in which DCT function is perturbed have provided critical insights into the physiological role of the DCT, and how transport is regulated. These include Familial Hyperkalemic Hypertension, the salt-wasting diseases Gitelman syndrome and EAST syndrome, and hereditary hypomagnesemias. The DCT is also established as an important target for the hormones angiotensin II and aldosterone; it also appears to respond to sympathetic-nerve stimulation and changes in plasma potassium. Here, we discuss what is currently known about DCT physiology. Early studies that determined transport rates of ions by the DCT are described, as are the channels and transporters expressed along the DCT with the advent of molecular cloning. Regulation of expression and activity of these channels and transporters is also described; particular emphasis is placed on the contribution of genetic forms of DCT dysregulation to our understanding.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
西瓜完成签到 ,获得积分10
刚刚
小张完成签到,获得积分10
1秒前
EVEN发布了新的文献求助30
2秒前
王冉冉发布了新的文献求助10
2秒前
2秒前
研无止境w发布了新的文献求助10
3秒前
5秒前
奶油泡fu完成签到 ,获得积分10
5秒前
dong东包完成签到,获得积分20
6秒前
6秒前
ED应助cccccc采纳,获得10
6秒前
shangziru发布了新的文献求助10
7秒前
漠之梦完成签到,获得积分20
8秒前
sc完成签到,获得积分10
8秒前
谦让的含海完成签到,获得积分10
8秒前
好运連連完成签到,获得积分10
9秒前
11秒前
liu完成签到,获得积分10
11秒前
飞翔的霸天哥应助Yuanchaoyi采纳,获得30
12秒前
香蕉觅云应助WJH采纳,获得10
13秒前
汉堡包应助研友_LOoomL采纳,获得10
13秒前
小二郎应助Felix采纳,获得10
13秒前
zaphkiel完成签到 ,获得积分10
14秒前
健壮的囧完成签到,获得积分10
15秒前
torch132完成签到,获得积分10
16秒前
桐桐应助阿景采纳,获得10
17秒前
17秒前
震动的平松完成签到 ,获得积分10
17秒前
Ting完成签到 ,获得积分10
18秒前
18秒前
Hello应助王冉冉采纳,获得30
19秒前
Ava应助Jarvi采纳,获得10
19秒前
20秒前
21秒前
22秒前
一枚研究僧完成签到,获得积分0
22秒前
22秒前
赘婿应助科研通管家采纳,获得10
23秒前
英姑应助科研通管家采纳,获得10
23秒前
思源应助科研通管家采纳,获得10
23秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038569
求助须知:如何正确求助?哪些是违规求助? 3576279
关于积分的说明 11374944
捐赠科研通 3305979
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815048