骨质疏松症
破骨细胞
骨吸收
成骨细胞
骨重建
背景(考古学)
骨细胞
医学
代谢性骨病
小RNA
骨病
平衡
生物信息学
癌症研究
内分泌学
内科学
生物
受体
遗传学
体外
基因
古生物学
作者
Junying Chen,Min Qiu,Ce Dou,Zhen Cao,Shiwu Dong
摘要
Preclinical Research Bone is a rigid and dynamic organ that undergoes continuous turnover. Bone homeostasis is maintained by osteoclast-mediated bone resorption and osteoblast-mediated bone formation. The interruption of this balance can cause various diseases, including osteoporosis a public health issue due to the rate of hip fracture, the most serious outcome of osteoporosis. The bone loss in osteoporosis results from an increase in bone resorption versus bone formation. Thus, regulation of osteoblast and osteoclast activity is a main focus in the treatment of osteoporosis. MicroRNAs (miRNAs) are a class of single stranded noncoding RNAs consisting of 18-22 nucleotides that have an important role in cell differentiation, cell fate, apoptosis, and pathogenesis in various disease states. The potential therapeutic and biomarker function of miRNAs in treating bone disorders is receiving more attention. The current review summarizes the role of miRNAs in bone function at a cellular level in the context of their therapeutic potential.
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