化学
苯酚
镍
催化作用
键裂
三嗪
组合化学
药物化学
有机化学
作者
Yaoyao Wang,Jun Shen,Qun Chen,Liang Wang,Mingyang He
标识
DOI:10.1016/j.cclet.2018.09.009
摘要
A nickel-catalysed reduction of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine (TCT) in ecofriendly 2-methyltetrahydrofuran (2-MeTHF) is described. The phenol-TCT derivatives were readily prepared using grinding method in short time without further purification. This catalytic system allowed the facile C–O cleavage of phenol-TCT derivatives under mild reaction conditions with high efficiency and good functional group tolerance. Gram-scale reaction was also achieved. Particularly, sequential functionalization of phenol-TCT derivatives followed by C–O bond reduction could also be realized, affording the high value-added products in moderate to good yields.
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