离子通道
乙酰胆碱受体
烟碱激动剂
化学
配体门控离子通道
配体(生物化学)
蜘蛛毒素
嘌呤能受体
生物
生物物理学
生物化学
受体
谷氨酸受体
出处
期刊:Toxin Reviews
[Informa]
日期:2019-03-07
卷期号:40 (2): 131-144
被引量:2
标识
DOI:10.1080/15569543.2019.1579230
摘要
Ligand-gated ion channels (LGIC) are membranous proteins that allow ionic flow across plasma membrane upon ligand binding. The channels are implicated in many physiological and pathological processes. Understanding the functionality of LGIC leads to a better understanding of normal physiology, as well as diseases. One of many approaches to study LGIC is through the development of new ligands. Natural products provide a rich source of such ligands. Spider venom includes biologically active compounds with different mechanisms of action. Some components target LGIC. The current review summarizes toxins of spider origin that act on glutamate receptors, nicotinic acetylcholine receptors (nAChRs), and purinergic receptors.
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