血管生成
血管内皮生长因子
细胞生物学
血管内皮生长因子B
嗜酸性粒细胞
内皮干细胞
血管内皮生长因子C
免疫学
状态5
壁细胞
调节器
血管生成
生物
癌症研究
血管内皮生长因子A
信号转导
血管内皮生长因子受体
体外
祖细胞
干细胞
哮喘
基因
生物化学
作者
Felicitas Bucher,Jung-Ho Lee,Sanghee Shin,Minseok S. Kim,Yong‐Seok Oh,Sanghoon Ha,Hongkai Zhang,Kyungmoo Yea
出处
期刊:Cytokine
[Elsevier]
日期:2018-10-01
卷期号:110: 397-403
被引量:13
标识
DOI:10.1016/j.cyto.2018.06.021
摘要
Interleukin-5 (IL-5) is best known as key regulator in eosinophil-associated diseases such as asthma. While a connection to vascular changes in eosinophil-associated lung diseases is still elusive, recent evidence suggests that IL-5 may have an atheroprotective role. Here, we report an unexpected anti-angiogenic potential of IL-5 on vascular endothelial cells in vitro. IL-5 significantly inhibited fundamental functions of human lung microvascular endothelial cells (HMVEC-L) in vessel formation including VEGF-induced endothelial cell proliferation, migration and tube formation. Knockdown (KD) of STAT5 abolished the direct anti-angiogenic effect of IL-5 on VEGF-induced endothelial cell proliferation, migration and tube formation.
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