Cu‐Catalyzed Directed C7−H Imidation of Indolines via Cross‐Dehydrogenative Coupling

Abstract Cu(I)‐catalyzed C7−H imidation of indolines via cross‐dehydrogenative coupling is developed. The reaction involves C−H activation of indolines via six‐membered metallacycle and various imides were coupled with indolines, with a broad substrate scope, and functional groups tolerance. Only oxygen is required for the catalytic process. A reversible C−H bond metalation process has been observed in the preliminary mechanistic interrogation. magnified image