亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Profiling and comparison of toxicant metabolites in hair and urine using a mass spectrometry-based metabolomic data processing method

毒物 尿 化学 代谢物 色谱法 邻苯二甲酸盐 代谢组学 代谢组 生物化学 毒性 有机化学
作者
Chia-Lung Shih,Hsin-Yi Wu,Pao-Mei Liao,Jen-Yi Hsu,Chia-Yun Tsao,Victor G. Zgoda,Pao‐Chi Liao
出处
期刊:Analytica Chimica Acta [Elsevier BV]
卷期号:1052: 84-95 被引量:16
标识
DOI:10.1016/j.aca.2018.11.009
摘要

Urine and hair are used for assessing human exposure to toxicants. Urine tests can show acute toxicant exposure. Hair analysis can be used to determine chronic toxicant exposure after months to years; however, compared to urine, hair analysis in exposure assessments is much less frequently investigated. Urine and hair are different matrices, and their mechanisms of toxicant metabolite incorporation are different. The toxicant metabolites present in urine and hair may also be different. To clarify this issue, a procedure was developed to identify toxicant metabolites in rat samples using a mass spectrometry-based metabolomic data processing method. Di-(2-propylheptyl) phthalate (DPHP), an industrial plasticizer, was used as the model toxicant. The developed procedure identified not only known DPHP metabolites (mono-(propyl-6-oxo-heptyl) phthalate, mono-(propyl-6-hydroxyheptyl) phthalate, and mono-(propyl-6-carboxyhexyl) phthalate) but also novel metabolites that were structurally related to DPHP in the rat samples, indicating that the developed procedure successfully identified toxicant metabolites in in vivo samples. Among the 62 tentative metabolites identified from the 7th-day urine and the 28th-day hair samples, 33 were detected in only the urine samples, 19 were detected in only the hair samples, and 10 were identified in both the urine and hair samples. A total of 15 out of the 62 metabolites were confirmed as DPHP structure-related metabolites based on MS/MS analysis. Among the 15 DPHP structure-related metabolites, only 2 metabolites were present in both the urine and hair samples. These results suggested that the metabolites identified in urine could not be applied to exposure assessments based on hair analysis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
lan发布了新的文献求助10
3秒前
4秒前
一杆长空完成签到,获得积分10
6秒前
热情的未来完成签到,获得积分20
12秒前
义气的蝴蝶完成签到,获得积分10
13秒前
14秒前
临水思长完成签到,获得积分10
15秒前
Lyuhng+1完成签到 ,获得积分10
16秒前
jyy应助薄红采纳,获得10
29秒前
30秒前
量子星尘发布了新的文献求助10
32秒前
kdjm688发布了新的文献求助10
37秒前
科研通AI2S应助cos采纳,获得10
40秒前
FashionBoy应助cos采纳,获得10
40秒前
多情的忆之完成签到,获得积分10
51秒前
pamper完成签到 ,获得积分10
51秒前
52秒前
58秒前
零度完成签到 ,获得积分10
1分钟前
kdjm688发布了新的文献求助10
1分钟前
超级微笑完成签到 ,获得积分10
1分钟前
1分钟前
领导范儿应助完美的流沙采纳,获得10
1分钟前
酷酷的枕头完成签到,获得积分10
1分钟前
刘明坤完成签到 ,获得积分10
1分钟前
SMULJL发布了新的文献求助10
1分钟前
带虾的烧麦完成签到,获得积分10
1分钟前
kdjm688发布了新的文献求助30
1分钟前
克姑美完成签到 ,获得积分10
1分钟前
CipherSage应助杜本内采纳,获得10
1分钟前
123完成签到,获得积分10
1分钟前
SMULJL完成签到,获得积分10
1分钟前
1分钟前
123发布了新的文献求助30
1分钟前
嗯哼哈哈完成签到 ,获得积分10
1分钟前
1分钟前
纯情的无色完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
1分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976608
求助须知:如何正确求助?哪些是违规求助? 3520700
关于积分的说明 11204542
捐赠科研通 3257350
什么是DOI,文献DOI怎么找? 1798716
邀请新用户注册赠送积分活动 877881
科研通“疑难数据库(出版商)”最低求助积分说明 806613